二氟孕甾丁酯

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(±)-樟脑(合成)
2′,4′-二羟基-4,6′-二甲氧基查尔酮
Alstonic acid A
溴乙烯
3-缩酮
(S,R)-(+)-(3,5-二氧杂-4-磷杂环庚二烯并[2,1-a:3,4-a′]二萘-4-基)-(1-苯基乙基)胺

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中文名	二氟孕甾丁酯
英文名	[(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
中文别名	二氟泼尼酯 \| 双氟泼尼酯
英文别名	更多

描述

Difluprednate(Durezol)是一种皮质类固醇，可作用于术后眼睛疼痛和炎症。

相关类别

信号通路 >>

其他 >>

其他

研究领域 >>

炎症/免疫

溶解度

体外：

DMSO：≥44mg / mL（86.52 mM）

H ₂ O：<0.1 mg / mL（不溶）

* “≥”表示可溶，但饱和度未知。

体内：1。逐个添加每种溶剂：10％DMSO 40％PEG300 5％吐温-80 45％盐水溶解度：≥2.5mg/ mL（4.92mM）;澄清溶液2.逐个添加每种溶剂：10％DMSO 90％玉米油溶解度：≥2.5mg / mL（4.92 mM）;澄清溶液3.逐个加入各溶剂：10％DMSO 90％（20％SBE-β-CD在盐水中）溶解度：2.5mg / mL（4.92mM）;暂停解决方案;需要超声波

储备液

1 mM	1.9664 mL	9.8319 mL	19.6637 mL
5 mM	0.3933 mL	1.9664 mL	3.9328 mL
10 mM	0.1966 mL	0.9832 mL	1.9664 mL

存储

粉末	-20℃下	3年
	4℃下	2年
在溶剂中	-80℃下	6个月
	-20℃下	1个月

运输

室温;可能会有所不同

SMILES

O=C([C@]([C@]12C)(CC[C@@]1([H])[C@@](C[C@H](F)C3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C2)OC(CCC)=O)COC(C)=O

参考文献

[1]. Difluprednate, From Wikipedia

相关活性
小分子

密度	1.3±0.1 g/cm3
沸点	600.3±55.0 °C at 760 mmHg
熔点	192 – 194?C
分子式	C₂₇H₃₄F₂O₇
分子量	508.552
闪点	316.9±31.5 °C
精确质量	508.227264
PSA	106.97000
LogP	3.67
外观性状	固体;White to Light yellow powder to crystal
蒸汽压	0.0±3.9 mmHg at 25°C
折射率	1.545
储存条件	0-10°C;避免加热
水溶解性	水溶性：不溶；水溶解度：0.008 g/l ?；可溶于：乙醇,甲醇,氯仿；极微溶：二乙醚

二氟孕甾丁酯毒性英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
RTECS号	TU3831500

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Difluprednate (6α,9-difluoro-11β,17,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate 17-butyrate, DFBA) has long been used as an anti-inflammatory dermatological agent. The main objectives of the c…

Butanoic acid, (6α,11β)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-3,20-dioxopregna-1,4-dien-17-yl ester

Myser

Difluoroprednisolone butyrate acetate

(6α,11β)-21-Acetoxy-6,9-difluoro-11-hydroxy-3,20-dioxopregna-1,4-dien-17-yl butyrate

UNII-S8A06QG2QE

Difluprednate

6a,9-Difluoro-11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-Acetate 17-Butyrate

(6a,11b)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dione

6α,9-Difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-butyrate

(6α,11β)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-3,20-dioxopregna-1,4-dien-17-yl butanoate

6ALPHA,9ALPHA-DIFLUOROPREDNISOLONE 21-ACETATE 17-BUTYRATE

Durezol

6a,9a-Difluoroprednisolone-21-acetate-17-butyrate

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)-, (6α,11β)-

DFBA

Epitopic

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二氟孕甾丁酯

品牌商品推荐

(±)-樟脑(合成)

2′,4′-二羟基-4,6′-二甲氧基查尔酮

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(S,R)-(+)-(3,5-二氧杂-4-磷杂环庚二烯并[2,1-a:3,4-a′]二萘-4-基)-(1-苯基乙基)胺

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