佐芬普利钙

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中文名	佐芬普利钙
英文名	zofenopril calcium
中文别名	[(4S)-3-(苯甲酰硫基)-2(S)-甲基丙酰-4-(苯硫基)-L-脯氨酸]钙盐
英文别名	更多

描述

Zofenopril Calcium(SQ26991)是抗氧化剂和血管紧张素转化酶（ACE）抑制剂。

相关类别

信号通路 >>

代谢酶/蛋白酶 >>

血管紧张素转换酶(ACE)

研究领域 >>

心血管疾病

溶解度

体外：

DMSO：2 mg / mL（4.46 mM;需要超声波）

储备液

1 mM	2.2293 mL	11.1463 mL	22.2926 mL
5 mM	0.4459 mL	2.2293 mL	4.4585 mL
10 mM	0.2229 mL	1.1146 mL	2.2293 mL

存储

粉末	-20°C	3年
?	4°C	2年
在溶剂中	-80°C	6月
?	-20°C	1月

运输

室温;可能会有所不同

SMILES

O=C(N(C[C@@H](SC1=CC=CC=C1)C2)[C@@H]2C([O-])=O)[C@H](C)CSC(C3=CC=CC=C3)=O.[0.5Ca2+]

参考文献

[1]. Dal Bo, L., P. Mazzucchelli, and A. Marzo, Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Biomed Sci Appl, 2000. 749(2): p. 287-94.

[2]. Kalender, A.M., et al., Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model. J Brachial Plex Peripher Nerve Inj, 2009. 4: p. 6.

[3]. Frascarelli, S., et al., Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling. J Cardiovasc Pharmacol, 2009. 54(5): p. 456-63.

相关活性
小分子

密度	1.34 g/cm3
沸点	646.3?C at 760 mmHg
熔点	>250?C
分子式	C₂₂H₂₂Ca_0.5NO₄S₂
分子量	448.58
闪点	344.7?C
PSA	228.56000
LogP	7.80660
外观性状	白色或发白的结晶粉末
储存条件	Refrigerator

佐芬普利钙MSDS英文版

符号	GHS09
信号词	Warning
危害声明	H410
警示性声明	P273-P501
危害码 (欧洲)	N
风险声明 (欧洲)	50/53
安全声明 (欧洲)	60-61
危险品运输编码	UN 3077 9 / PGIII

(4S)-l-[(2S)-3-...

81938-42-3

佐芬普利钙

81938-43-4

文献：WO2007/3963 A1, ; Page/Page column 9; 11-12 ;

(4S)-1((2S)-3-(...

81938-38-7

佐芬普利钙

81938-43-4

文献：US2009/176860 A1, ; Page/Page column 3 ;

佐芬普利

81872-10-8

佐芬普利钙

81938-43-4

文献：WO2010/84515 A2, ; Page/Page column 34 ;

zofenopril tert...

1236133-15-5

佐芬普利钙

81938-43-4

文献：WO2010/84515 A2, ; Page/Page column 33-34 ;

佐芬普利钙上游产品? 3
CAS号81938-42-3 (4S)-l-[(2S)-3-... CAS号81938-38-7 (4S)-1((2S)-3-(... CAS号81872-10-8 佐芬普利
佐芬普利钙下游产品? 0

佐芬普利钙上游产品? 3

CAS号81938-42-3
(4S)-l-[(2S)-3-...

CAS号81938-38-7
(4S)-1((2S)-3-(...

CAS号81872-10-8
佐芬普利

佐芬普利钙下游产品? 0

Zofenopril plus hydrochlorothiazide fixed combination in the treatment of hypertension and associated clinical conditions.

Cardiovasc. Ther. 27(4) , 275-88, (2009)

Zofenopril, is a highly lipophilic ACE inhibitor, characterized by long-lasting tissue penetration and sustained cardiac ACE inhibition, indicated for the treatment of hypertension and myocardial infa...

Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of zofenopril and its active metabolite zofenoprilat in human plasma.

J. Pharm. Biomed. Anal. 55(3) , 527-32, (2011)

A novel, sensitive and rapid liquid chromatographic-electrospray ionization mass spectrometric method was developed and validated for the determination of zofenopril and its active metabolite zofenopr...

Effects of zofenopril and ramipril on cough reflex responses in anesthetized and awake rabbits.

J. Cardiovasc. Pharmacol. Ther. 15(4) , 384-92, (2010)

Cough is the most common symptom reported by patients in a primary care setting and is one of the most frequent secondary effects recorded during treatment with angiotensin-converting enzyme (ACE) inh...

Calcium bis[(2S,4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)-2-pyrrolidinecarboxylate]

ZOFENOPRIL CALCIUM

Calcium bis[(2S,4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)pyrrolidine-2-carboxylate]

L-Proline, 1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, calcium salt, (4S)- (2:1)

MFCD08704648

Zofenopril calcium salt

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佐芬普利钙

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