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| 描述 |
Eliprodil(SL-820715)是NR2B-NMDA受体高效选择性抑制剂，IC50值1uM，对NR2A-和NR2C-NMDA受体作用弱。 |
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| 相关类别 |
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| 溶解度 |
体外：
DMSO：14.29 mg / mL（41.08 mM;需要超声波） 体内：1。逐个添加每种溶剂：10％DMSO 40％PEG300 5％吐温-80％45％盐水溶解度：1.43 mg / mL（4.11 mM）;暂停解决方案;需要超声波2.逐个添加每种溶剂：10％DMSO 90％玉米油溶解度：≥1.43mg / mL（4.11 mM）;明确解决方案
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| 储备液 |
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| 存储 |
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| 运输 |
室温;可能会有所不同 |
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| SMILES |
ClC(C=C1)=CC=C1C(O)CN(CC2)CCC2CC3=CC=C(F)C=C3 |
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| 参考文献 |
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| 相关活性 小分子 |
(+)-MK 801 马来酸盐(马来酸地佐环平)(mM/ml) | 6-氰基-7-硝基喹喔啉-2,3-二酮 | N-甲基-D-天冬氨酸水合物 | 酒石酸艾芬地尔 | (R)-(-)-2-氨基-5-膦酰戊酸 | 6,7-二硝基奎喔林-2,3(1H,4H)-二酮 | Ro 25-6981马来酸盐 | 马来酸氟吡汀 | Mibampator | 苯并二氧六环-6-(1-哌啶基)甲酰胺 | Naspm | (8R)-7-乙酰基-5-(4-氨基苯基)-8,9-二氢-8-甲基-7H-1,3-二氧杂环戊烯并[4,5-H][2,3]苯并二氮杂卓 | 盐酸甲氯芬酯 | 24羟基胆固醇 |
| 密度 | 1.205 g/cm3 |
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| 沸点 | 474.1?C at 760 mmHg |
| 分子式 | C20H23ClFNO |
| 分子量 | 347.85400 |
| 闪点 | 240.5?C |
| 精确质量 | 347.14500 |
| PSA | 23.47000 |
| LogP | 4.40510 |
| 外观性状 | 固体 |
| 蒸汽压 | 8.57E-10mmHg at 25°C |
| 折射率 | 1.58 |
| 符号 |
GHS07, GHS09 |
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| 信号词 |
Warning |
| 危害声明 |
H319-H410 |
| 警示性声明 |
P273-P305 + P351 + P338-P501 |
| 个人防护装备 |
Eyeshields;Gloves |
| 危害码 (欧洲) |
N: Dangerous for the environment; |
| 风险声明 (欧洲) |
R50/53 |
| 安全声明 (欧洲) |
60-61 |
| 危险品运输编码 | UN 3077 9/PG 3 |
| 海关编码 | 2933399090 |
| 海关编码 | 2933399090 |
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| 中文概述 | 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 |
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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NMDA receptor antagonists do not block the development of sensitization of catalepsy, but make its expression state-dependent. Behav. Pharmacol. 12(2) , 143-9, (2001)
Dopamine (DA) receptor blockade induces catalepsy in rats which increases in strength upon retesting. This increase in catalepsy represents a form of sensitization which has been shown to be completel…
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Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists. Bioorg. Med. Chem. Lett. 10(12) , 1377-80, (2000)
A short synthesis of the NMDA receptor antagonist (rac)-Eliprodil (9) and its resolution into the enantiomers by chiral HPLC is described. The enantiomers (R)-9 and (S)-9 were found to exhibit markedl…
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The sequential analysis of repeated binary responses: a score test for the case of three time points. Stat. Med. 25(13) , 2196-214, (2006)
In this paper a robust method is developed for the analysis of data consisting of repeated binary observations taken at up to three fixed time points on each subject. The primary objective is to compa…
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eliprodil |
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