描述 |
依普菌素(Eprinomectin; MK-397)是一种阿维菌素,具有驱虫,杀虫杀螨活性。 |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
相关类别 |
|
||||||||||||
溶解度 |
体外:
DMSO:≥46mg / mL(50.32 mM) * “≥”表示可溶,但饱和度未知。
|
||||||||||||
储备液 |
|
||||||||||||
存储 |
|
||||||||||||
运输 |
室温;可能会有所不同 |
||||||||||||
SMILES |
C[C@H]1[C@@H](NC(C)=O)[C@@H](OC)C[C@H](O[C@@H]2[C@H](C)O[C@@H](O[C@@H](/C(C)=C/C[C@@H](C3)OC4(O[C@@H]([C@@H](CC)C)[C@H](C)C=C4)C[C@H]3OC5=O)[C@@H](/C=C/C=C6CO[C@@H]7[C@@]6(O)[C@H]5C=C(C)[C@H]7O)C)C[C@@H]2OC)O1 |
||||||||||||
参考文献 |
|
||||||||||||
相关活性 小分子 |
硫酸羟基氯喹 | 甲硝唑 | Emetine dihydrochloride hydrate | 伊维菌素 | 青蒿素 | 盐酸左旋咪唑 | 氟雷拉纳 | RRX-001 | 阿维菌素 | 奎尼丁 | 硫氯酚 | 氟苯咪唑 | 甲苯达唑 | SQ109 | 蒿甲醚 |
密度 | 1.23 |
---|---|
熔点 | 163-166 ?C |
分子式 | C50H75NO14 |
分子量 | 914.13 |
闪点 | 2?°C |
PSA | 178.93000 |
LogP | 5.46970 |
储存条件 |
密封、在2 ?C -8 ?C下保存 |
计算化学 |
1.疏水参数计算参考值(XlogP):3.5 2.氢键供体数量:3 3.氢键受体数量:14 4.可旋转化学键数量:8 5.互变异构体数量:2 6.拓扑分子极性表面积179 7.重原子数量:64 8.表面电荷:0 9.复杂度:1830 10.同位素原子数量:0 11.确定原子立构中心数量:19 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:3 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
更多 |
1. 性状:未确定 2. 密度(g/mL,20℃):1.23 3. 相对蒸汽密度(g/mL,空气=1):未确定 4. 熔点(?C):163-166 5. 沸点(?C,常压):未确定 6. 沸点(?C,KPa):未确定 7. 折射率:未确定 8. 闪点(?C):2 9. 比旋光度(?):未确定 10. 自燃点或引燃温度(?C):未确定 11. 蒸气压(Pa,20?C):未确定 12. 饱和蒸气压(KPa,20?C):未确定 13. 燃烧热(KJ/mol):未确定 14. 临界温度(?C):未确定 15. 临界压力(KPa):未确定 16. 油水(辛醇/水)分配系数的对数值:未确定 17. 爆炸上限(%,V/V):未确定 18. 爆炸下限(%,V/V):未确定 19. 溶解性:未确定 |
符号 |
GHS06, GHS08, GHS09 |
---|---|
信号词 |
Danger |
危害声明 |
H301-H361-H400 |
警示性声明 |
P273-P281-P301 + P310 |
个人防护装备 |
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
危害码 (欧洲) |
F,Xn,N,T |
风险声明 (欧洲) |
11-20/21/22-36-62-50/53-25-63 |
安全声明 (欧洲) |
26-36/37-16-61-60-45 |
危险品运输编码 | UN 2811 |
WGK德国 | 3 |
Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel, against the ticks, Ixodes ricinus and Ixodes scapularis, on cats. Vet. Parasitol. 202(1-2) , 59-63, (2014)
Five controlled, blinded and randomized studies were conducted to examine the efficacy of a single topical application of a combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel (BRO…
|
|
Efficacy of a single dose of a novel topical combination product containing eprinomectin to prevent heartworm infection in cats Vet. Parasitol. 202(1-2) , 49-53, (2014)
Cats may be infected by heartworm, Dirofilaria immitis, through mosquito bites. They can develop severe heartworm disease when infective D. immitis larvae migrate and develop into adults in the pulmon…
|
|
Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against experimental infections ofToxascaris leoninain cats Vet. Parasitol. 202(1-2) , 40-4, (2014)
The efficacy of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination product (BROADLINE?, Merial) was evaluated against adult Toxascaris leonina ascarids in experimental…
|
|
(4”R)-4”-(Acetylamino)-4”-deoxyavermectin B1 |
(1′R,2S,4′S,5S,6R,8′R,10′E,12′S,13′S,14′E,16′E,20′R,21′R,24′S)-21′,24′-Dihydroxy-6-isopropyl-5,11′,13′,22′-tetramethyl-2′-oxo-5,6-dihydrospiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1.0]pentacosa[10,14,16,22]tetraen]-12′-yl 4-O-(4-acetamido-2,4,6-trideoxy-3-O-methyl-α-L-lyxo-hexopyranosyl)-2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranoside – (1′R,2S,4′S,5S,6R,8′R,10′E,12′S,1 3′S,14′E,16′E,20′R,21′R,24′S)-6-[(2S)-2-buta |
Eprinomectin |
Eprinex |
EINECS 200-835-2 |
MFCD07370747 |