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依曲替酯
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| 描述 |
Etretinate(Ro 10-9359)是一用于治疗银屑病的药物，临床上已被acitretin取代使用。 |
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| 溶解度 |
体外：
DMSO：25 mg / mL（70.53 mM;需要超声波） 体内：1。逐个添加每种溶剂：10％DMSO 90％玉米油溶解度：≥2.5mg / mL（7.05 mM）;明确解决方案
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| 存储 |
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| 运输 |
室温;可能会有所不同 |
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| SMILES |
O=C(OCC)/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C=C(OC)C(C)=C1C |
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| 相关活性 小分子 |
磺丁醚-beta-环糊精 | 环孢菌素 | 2,7-二氯二氢代荧光黄二醋酸 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | 4′,4”-双-2-咪唑啉-2-基对苯二丙烯酰苯胺二盐酸盐 | 乙莫克舍 | TD139 | Mitoquinone甲磺酸盐 | GSK2795039 | 5,5’,6,6’-四氯-1,1’,3,3’-四乙基苯并咪唑羰花青碘化物 | 胞内钙荧光探针 BAPTA-AM | AP20187 | GKT137831 | D-虫荧光素游离酸 | 野百合碱 |
| 密度 | 1.0±0.1 g/cm3 |
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| 沸点 | 506.4±38.0 °C at 760 mmHg |
| 熔点 | 104-105?C |
| 分子式 | C23H30O3 |
| 分子量 | 354.483 |
| 闪点 | 219.4±21.4 °C |
| 精确质量 | 354.219482 |
| PSA | 35.53000 |
| LogP | 6.77 |
| 外观性状 | 结晶固体 |
| 蒸汽压 | 0.0±1.3 mmHg at 25°C |
| 折射率 | 1.544 |
| 储存条件 | Amber Vial, -20°C Freezer |
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依曲替酯毒性英文版
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| 危险品运输编码 | NONH for all modes of transport |
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| 依曲替酯上游产品? 3 | |
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| 依曲替酯下游产品? 0 | |
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Systemic retinoids in the management of ichthyoses and related skin types. Dermatol. Ther. 26(1) , 26-38, (2013)
The term retinoid includes both natural and synthetic derivatives of vitamin A. Retinoid-containing treatments have been used since ~1550BC by the early Egyptians. Treatment of ichthyosiform disorders…
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The effects of alcohol on the metabolism and toxicology of anti-psoriasis drugs. Expert Opin. Drug Metab. Toxicol. 8(8) , 959-72, (2012)
Alcohol has long been suspected to be a triggering and precipitating factor of psoriasis. Alcohol misuse is common in patients with moderate-to-severe psoriasis and appears to impair treatment outcome…
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Generalized pustular psoriasis in a child: observation of long-term combination therapy with etretinate and calcipotriol for 16 years. Pediatr. Dermatol. 29(2) , 206-8, (2012)
Generalized pustular psoriasis (GPP) is a rare condition in young children. It is difficult to treat and may require long-term systemic therapy. We report the long-term course of a 3-year-old boy whos…
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ethyl (all-E)-9-(4-methyoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate |
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2,4,6,8-Nonatetraenoic acid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-, ethyl ester |
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Retinoid |
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9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid ethyl ester |
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Ethyl etrinoate |
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Ro 10-9359 |
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Etretinatum [INN-Latin] |
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Etretinato |
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ethyl (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate |
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Etretinatum |
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ethyl all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate |
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EINECS 259-119-3 |
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MFCD00866624 |
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Ethyl 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate |
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Etretinato [INN-Spanish] |
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Tegison |
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