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决明蒽醌

决明蒽醌

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?决明蒽醌名称


















中文名

决明蒽醌
英文名

2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione
中文别名


美决明子素




|



2,8-二羟基-1-甲氧基-3-甲基蒽醌



英文别名
更多





?决明蒽醌生物活性










































描述
Obtusifolin 是从决明子的种子中分离出，通过抑制 NF-kB 通路来调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。Obtusifolin 通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。
相关类别


靶点

NF-κB
体外研究

钝叶素（1，10，100μM）抑制EGF、PMA或TNF-α诱导的NCI-H292细胞MUC5AC基因表达[1]。
存储

请将产品存放在分析证书中的建议条件下。


运输

室温
SMILES

O=C1C2=C(C=CC=C2O)C(C3=CC(C)=C(O)C(OC)=C13)=O
参考文献

[1]. Choi BS, et al. Obtusifolin isolated from the seeds of Cassia obtusifolia regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via affecting NF-κB pathway. Phytother Res. 2019 Apr;33(4):919-928.

[2]. Hsu YL, et al. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein. J Agric Food Chem. 2014 Dec 10;62(49):11933-40.






?决明蒽醌物理化学性质







































密度 1.448±0.06 g/cm3
沸点 528.0±50.0 °C at 760 mmHg
熔点 242-243?C
分子式 C16H12O5
分子量 284.263
闪点 202.2±23.6 °C
精确质量 284.068481
PSA 83.83000
LogP 4.18
蒸汽压 0.0±1.4 mmHg at 25°C
折射率 1.678
水溶解性 Insuluble (2.6E-3 g/L) (25 ?C)





?决明蒽醌合成线路






































(1R,4aS,9aR)-9a-chloro-8-hydroxy-1-methoxy-3-methyl-1,2-bis((trimethylsilyl)oxy)-1,4,4a,9a-tetrahydroanthracene-9,10-dione结构式

(1R,4aS,9aR)-9a…

108637-81-6




~0%







决明蒽醌结构式

决明蒽醌

477-85-0









1,2,8-三羟基-3-甲基蒽醌结构式

1,2,8-三羟基-3-甲基蒽醌

58322-78-4





文献：Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 – 5002





methyl 3-methyl-2-trimethylsilyloxybut-2-enoate结构式

methyl 3-methyl…

108637-71-4




~%







决明蒽醌结构式

决明蒽醌

477-85-0


文献：Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 – 5002





未登录结构式

未登录

127042-39-1




~98%







决明蒽醌结构式

决明蒽醌

477-85-0


文献：Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 – 5176





(1S,4aR,9aS)-8-hydroxy-1-methoxy-3-methyl-1,2-bis((trimethylsilyl)oxy)-1,4,4a,9a-tetrahydroanthracene-9,10-dione结构式

(1S,4aR,9aS)-8-…

108637-77-0




~60%







决明蒽醌结构式

决明蒽醌

477-85-0









1,2,8-三羟基-3-甲基蒽醌结构式

1,2,8-三羟基-3-甲基蒽醌

58322-78-4





文献：Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 – 5002





1-Methoxy-3-methyl-1,2-bis(trimethylsiloxy)-1,3-butadiene结构式

1-Methoxy-3-met…

108637-73-6




~%







决明蒽醌结构式

决明蒽醌

477-85-0


文献：Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 – 5002





2,3-dichloro-5-methoxy-1,4-naphthoquinone结构式

2,3-dichloro-5-…

71700-71-5




~%







决明蒽醌结构式

决明蒽醌

477-85-0


文献：Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 – 5176





(E)-3-methyl-4-methoxy-2-[(trimethylsilyl)oxy]-1,3-butadiene结构式

(E)-3-methyl-4-…

72476-03-0




~%







决明蒽醌结构式

决明蒽醌

477-85-0


文献：Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 – 5176





(3R,4S,4aS,9aR)-4a,9a-dichloro-4,8-dimethoxy-3-methyl-3,4,4a,9a-tetrahydroanthracene-2,9,10(1H)-trione结构式

(3R,4S,4aS,9aR)…

127042-37-9




~%







决明蒽醌结构式

决明蒽醌

477-85-0


文献：Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 – 5176





胡桃醌结构式

胡桃醌

481-39-0








1-Methoxy-3-methyl-1,2-bis(trimethylsiloxy)-1,3-butadiene结构式

1-Methoxy-3-met…

108637-73-6




~%







决明蒽醌结构式

决明蒽醌

477-85-0


文献：Krohn, Carsten; Khanbabaee, Karamali Liebigs Annalen der Chemie, 1993 , # 8 p. 905 – 910




















?决明蒽醌英文别名













































Anthraquinone,2,8-dihydroxy-1-methoxy-3-methyl


2,8-dihydroxy-1-methoxy-3-methyl-anthraquinone


Anthraquinone, 2,8-dihydroxy-1-methoxy-3-methyl-


9,10-Anthracenedione, 2,8-dihydroxy-1-methoxy-3-methyl-


2,8-Dihydroxy-1-methoxy-3-methyl-anthrachinon


obtusifoline


Obtusifolin (anthraquinone)


1,7-Dihydroxy-8-methoxy-6-methyl-9,10-anthraquinone


2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthraquinone


Obtusifolin


2,8-dihydroxy-1-methoxy-3-methylanhraquinone


2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthracenedione








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