利马前列素

中文名	利马前列素
英文名	(E)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S,5S)-3-hydroxy-5-methylnon-1-enyl]-5-oxocyclopentyl]hept-2-enoic acid
中文别名	利马司特 \| (2E,11Α,13E,15S,17S)-11,15-二羟基-17,20-二甲基-9-氧代前列-2,13-二烯-1-酸(2E,11Α,13E,15S,17S)-11,15-DIHYDROXY-17,20-DIMETHYL-9-OXOPROSTA-2,13-DIEN-1-OICACID
英文别名	更多

描述

Limaprost(OP1206)是PGE1类似物，是血小板粘附抑制剂。

相关活性
小分子

密度	1.1±0.1 g/cm3
沸点	550.6±50.0 °C at 760 mmHg
熔点	97-100°
分子式	C₂₂H₃₆O₅
分子量	380.518
闪点	300.9±26.6 °C
精确质量	380.256287
PSA	94.83000
LogP	3.15
外观性状	crystalline
蒸汽压	0.0±3.4 mmHg at 25°C
折射率	1.551
储存条件	?20°C
水溶解性	DMF: soluble
分子结构	1、摩尔折射率：108.52 2、摩尔体积（cm³/mol）：340.2 3、等张比容（90.2K）：908.2 4、表面张力（dyne/cm）：50.7 5、极化率（10-24cm3）：43.02
更多	1.性状：白色结晶。 2.熔点（℃）：97～100。

利马前列素毒性英文版

符号	GHS06
信号词	Danger
危害声明	H300
警示性声明	P264-P301 + P310
个人防护装备	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危害码 (欧洲)	T: Toxic;
风险声明 (欧洲)	25
安全声明 (欧洲)	36/37/39-45
危险品运输编码	UN 2811 6.1/PG 2
WGK德国	3
RTECS号	UK8362500

88mg化合物(I)和357mg4-二甲氨基吡啶溶于二氯甲烷，在冰浴冷却下加入116脚甲磺酰氯。加毕，在30℃反应2.5h，得到94%的化合物(Ⅱ)。80mg化合物(Ⅱ)和800mg锌在含乙酸的异丙醇中，在50℃反应2h，得到66%的化合物(Ⅲ)。再酸性(如三氟乙酸或甲磺酸)水解为化合物(Ⅳ)，最后用猪肝酯酶水解，得到利马前列素。

74397-12-9 preparation

OP-1206, a prostaglandin E1 derivative, attenuates the thermal hyperesthesia induced by constriction injury to the sciatic nerve in the rat.

Anesth. Analg. 80(3) , 515-20, (1995)

Nerve ischemia induces wallerian degeneration and peripheral neuropathy, the nerve constriction injury induces thermal hyperesthesia. Nerve ischemia is one possible mechanism in the development of the…

Inhibition of platelet aggregation by the cAMP-phosphodiesterase inhibitor, cilostamide, may not be associated with activation of cAMP-dependent protein kinase.

Cell. Signal. 4(4) , 453-63, (1992)

We examined the involvement of cAMP-dependent protein kinase (A kinase)2 in the inhibition by cilostamide, a specific inhibitor of the low Km cAMP-phosphodiesterase (PDE), on 9,11-epithio-11,12-methan…

Correlation between methotrexate-induced intestinal damage and decrease in polyamine content.

Life Sci. 72(6) , 669-76, (2002)

A synthetic analog of prostaglandin E(1), OP-1206 [17S, 20-dimethyl-trans-Delta(2)-prostaglandin E(1)] protects the small intestine from the methotrexate (MTX)-induced damage. The purpose of this stud…

17S,20-Dimethyl-trans-delta2-PGE1

(E)-7-((1R,2R,3R)-3-Hydroxy-2-((E)-(3S,5S)-3-hydroxy-5-methyl-1-nonenyl)-5-oxocyclopentyl)-2-heptenoic acid

(2E)-7-{(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methylnon-1-en-1-yl]-5-oxocyclopentyl}hept-2-enoic acid (non-preferred name)

Limaprost

(2E)-7-{(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl}-2-heptenoic acid

9-Oxo-11a,15a-dihydroxy-17S,20-dimethylprosta-trans-2,trans-13-dienoic Acid

17S,20-Dimethyl-trans-2,3-didehydro-PGE1

(2E,11a,13E,15S,17S)-11,15-Dihydroxy-17,20-dimethyl-9-oxoprosta-2,13-dien-1-oic Acid

17S-Methyl-w-homo-trans-D2-PGE1

ONO 1206

OP 1206

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