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| 描述 |
(20S)-Protopanaxatriol 是人参皂苷的代谢物，通过 glucocorticoid receptor 和 oestrogen receptor 起作用，同时为 LXRα 的抑制剂。 |
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| 相关类别 |
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| 靶点 |
Glucocorticoid receptor, Oestrogen receptor[1], LXRα[2]
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| 体外研究 |
（20S）-Protopanaxatriol通过人脐静脉内皮细胞（HUVEC）中的糖皮质激素受体（GR）和雌激素受体（ER）起作用。 （20S）-Protopanaxatriol（g-PPT）在HUVEC中增加[Ca2 +] i，EC50为482nM。 （20S）-Protopanaxatriol（1μM）通过ERβ提高NO产生[1]。 （20S）-Protopanaxatriol（PPT）抑制Gal4-LXRαLBD的自主反式激活，这是T0901317依赖的SREBP-1c及其启动子的转录。 （20S）-Protopanaxatriol（10μg/ mL）阻断RNA聚合酶II向SREBP-1c的LXRE区域的募集。 （20S）-Protopanaxatriol还抑制与脂肪生成相关的LXRα靶基因的T0901317依赖性转录，并减少T0901317诱导的原代肝细胞中的细胞甘油三酯（TG）积累，但不改变ABCA1的转录，也是LXRα靶基因的转录[2] 。 |
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| 溶解度 |
体外：
DMSO：≥47mg / mL（98.59 mM） * “≥”表示可溶，但饱和度未知。
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| 储备液 |
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| 存储 |
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| 运输 |
室温;可能会有所不同 |
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| SMILES |
C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O)C)(C[C@H](O)[C@@]2([H])C3(C)C)[C@]4([C@@]1([H])[C@]([C@@](C)(O)CC/C=C(C)/C)([H])CC4)C |
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| 参考文献 |
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| 相关活性 小分子 |
氢化可的松 | 米非司酮 | N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]-苯磺酰胺 | GW3965盐酸盐 | 皮质酮 | Elacestrant dihydrochloride | AZD9496 | 山奈酚 | 2-[(2-氯-4-氟苯基)甲基]-3-(4-氟苯基)-7-(三氟甲基)-2H-吲唑 | 3-[4-[[2,4-二(三氟甲基)苄基]氧基]-3-甲氧基苯基]-2-氰基-N-(5-三氟甲基-[1,3,4]噻二唑-2-基)丙烯酰胺 | 雌酚酮 | SR9243 | 泼尼松 | Brilanestrant | 27-羟基胆固醇 |
| 密度 | 1.1±0.1 g/cm3 |
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| 沸点 | 588.8±50.0 °C at 760 mmHg |
| 分子式 | C30H52O4 |
| 分子量 | 476.73 |
| 闪点 | 242.9±24.7 °C |
| PSA | 80.92000 |
| LogP | 5.41 |
| 蒸汽压 | 0.0±3.7 mmHg at 25°C |
| 折射率 | 1.541 |
| 危险品运输编码 | NONH for all modes of transport |
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Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis. J. Ethnopharmacol. 137 , 1542-1546, (2011)
Panax ginseng is a precious traditional Chinese herbal medicine which has been utilized as herbal tonic for improving immunity. The active component, ginsenosides have been shown to possess various ph…
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Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng. Plant Cell Physiol. 53 , 1535-1545, (2012)
Ginseng (Panax ginseng C.A. Meyer) is one of the most popular medicinal herbs, and the root of this plant contains pharmacologically active components, called ginsenosides. Ginsenosides, a class of te…
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The in vitro structure-related anti-cancer activity of ginsenosides and their derivatives. Molecules 16(12) , 10619-30, (2011)
Panax ginseng has long been used in Asia as a herbal medicine for the prevention and treatment of various diseases, including cancer. The current study evaluated the cytotoxic potency against a variet…
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PROTOPANAXTRIOL |
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20(S)-APPT,g-PPT |
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Gonane-3,6,12-triol, 17-[(1S)-1-hydroxy-1,5-dimethyl-4-hexen-1-yl]-4,4,10,14-tetramethyl-, (3β,6α,12β,14β,17β)- |
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(3β,6α,12β,14β)-4,4,14-Trimethyl-18-norcholest-24-ene-3,6,12,20-tetrol |
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20S-Protopanaxatriol |
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Protopanaxatriol, 20S- |
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(20S)-Protopanaxatriol |
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