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去乙酰毛花苷

去乙酰毛花苷

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?去乙酰毛花苷名称


















中文名

去乙酰毛花苷
英文名

deslanoside
中文别名


毛地黄苷C



英文别名
更多





?去乙酰毛花苷生物活性








































描述
Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷,用于治疗充血性心力衰竭和因折返机制引起的室上性心律失常,并在治疗慢性心房颤动时控制心室率。Deslanoside 抑制Na-K-ATPase膜泵,导致细胞内钠和钙浓度增加。
相关类别


体外研究

去乙酰甲苷(Desacetyllanatoside C)是兰豆苷C的代谢产物[4]。地塞米松增加前臂血流量和心脏指数,降低心率,同时骨骼肌交感神经活动显著降低,作为中枢介导交感神经系统活动的指标[1]。
存储

请将产品存放在分析证书中的建议条件下。


运输

室温
SMILES

O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](O[C@@](O[C@H](C)[C@H]3O[C@@](O[C@H](C)[C@H]4O[C@@](O[C@H](C)[C@H]5O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)([H])C[C@@H]5O)([H])C[C@@H]4O)([H])C[C@@H]3O)C1)C)([H])[C@]2([H])C[C@H]7O)(CC[C@@H]8C(CO9)=CC9=O)[C@]78C
参考文献

[1]. Hauptman PJ, et al. Digitalis. Circulation. 1999 Mar 9;99(9):1265-70.

[2]. Wang L, et al. Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in China. Sci Rep. 2017 Oct 23;7(1):13819.

[3]. Deslanoside.

[4]. Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45(3):231-8.

[5]. Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45(3):231-8.







?去乙酰毛花苷物理化学性质
































密度 1.4±0.1 g/cm3
熔点 220-235?C
分子式 C47H74O19
分子量 943.079
精确质量 942.482422
PSA 282.21000
LogP -1.40
折射率 1.620
储存条件 2-8°C





?去乙酰毛花苷毒性和生态




去乙酰毛花苷毒性英文版






?去乙酰毛花苷安全信息





















风险声明 (欧洲)
R23/25
安全声明 (欧洲)
1-22-45
危险品运输编码 UN 2811





?去乙酰毛花苷合成线路




















~%







去乙酰毛花苷结构式

去乙酰毛花苷

17598-65-1






文献:Helvetica Chimica Acta, , vol. 16, p. 1390,1407 Helvetica Chimica Acta, , vol. 17, p. 592,613









~%







去乙酰毛花苷结构式

去乙酰毛花苷

17598-65-1






文献:Advanced Synthesis and Catalysis, , vol. 355, # 13 p. 2518 – 2524





~91%







去乙酰毛花苷结构式

去乙酰毛花苷

17598-65-1






文献:Muramatsu, Wataru; Yoshimatsu, Hirofumi Advanced Synthesis and Catalysis, 2013 , vol. 355, # 13 p. 2518 – 2524







?去乙酰毛花苷上下游产品













去乙酰毛花苷上游产品? 3

去乙酰毛花苷下游产品? 1













?去乙酰毛花苷文献25

更多文献














Effects of acute administration of ethanol on experimental arrhythmia.

Chin. J. Physiol. 55(5) , 307-13, (2012)

Many studies have shown that the relationship between alcohol consumption and most cardiovascular diseases is U-shaped, with nondrinkers and heavier drinkers having higher risks than moderate drinkers…





Altered vagal and sympathetic control of heart rate in left ventricular dysfunction and heart failure.

Am. J. Physiol. 268(2 Pt 2) , R310-16, (1995)

We investigated alterations in autonomic control of heart rate in conscious dogs with left ventricular (LV) dysfunction in the presence and absence of heart failure (HF) due to rapid pacing. In dogs w…





Two-stage cultivation of Digitalis lanata cells: semicontinuous production of deacetyllanatoside C in 20-litre airlift bioreactors.

J. Biotechnol. 16(1-2) , 123-35, (1990)

A two-stage cultivation method was employed to develop a semicontinuous biotransformation process for the production of deacetyllanatoside C, a cardenolide of the important digoxin series. Digitoxin w…









?去乙酰毛花苷英文别名









































































































Card-20(22)-enolide, 3-((O-β-D-glucopyranosyl-(1->4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3β,5β,12β)-


Deacetyllanatoside C


Desacetyllanatoside C


Deslanatoside C


Deslanoside


Deacetyllanatoside C,Desacetyllanatoside C


Cedilanide


(3β,5β,12β)-3-{[β-D-Glucopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide


deacetyl-lanatoside


4-18-00-02455 (Beilstein Handbook Reference)


Desacetyldigilanide C


Descetyldigilanide C


DESLANOSIDUM


4-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-Dihydroxy-3-{[(2R,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-6-methyl-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2(5H)-furanone


Desaci


Desace


MFCD00135818


deacetyl-lanatoside C


Card-20(22)-enolide, 3-[[O-β-D-glucopyranosyl-(1->4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-12,14-d ihydroxy-, (3β,5β,12β)-


Deslanatoside


Purpurea Glycoside C


Desacetyllanatosid C


card-20(22)-enolide, 3-[[O-β-D-glucopyranosyl-(1->4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-12,14-dihydroxy-, (3β,5β,12β)-


glucodigoxin


Deslanosidum C


(3β,5β,12β)-3-{[β-D-Glucopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy}-12,14-dihydro
 xycard-20(22)-enolide


4-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-Dihydroxy-3-{[(2R,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-6-méthyl-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}tétrahydro-2H-pyran-2-yl]oxy}-6-méthyltétrahydro-2H-pyran-2-yl]oxy}-6-méthyltétrahydro-2H-pyran-2-yl]oxy}-10,13-diméthylhexadécahydro-1H-cyclopenta[a]phénanthrén-17-yl]-2(5H)-furanone


cedilanidd


sediranido


EINECS 241-568-1


de-O-acetyl-lanatoside C


4-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-Dihydroxy-3-{[(2R,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-6-methyl-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2(5H)-furanon








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