去亚甲基小檗碱

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中文名	去亚甲基小檗碱
英文名	9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol
英文别名	更多

描述	Demethyleneberberine 是一种天然线粒体靶向抗氧化剂。Demethyleneberberine 通过抑制 NF-κB 通路和调节 Th 细胞的平衡来减轻小鼠结肠炎并抑制炎症反应。Demethyleneberberine 可作为 AMPK 激活剂，用于治疗非酒精性脂肪性肝病 (NAFLD)。
相关类别	信号通路 >> 表观遗传学 >> AMPK 研究领域 >> 炎症/免疫信号通路 >> PI3K/Akt/mTOR 信号通路 >> AMPK 研究领域 >> 代谢疾病
SMILES	COC1=C(OC)C2=C[N+]3=C(C4=CC(O)=C(O)C=C4CC3)C=C2C=C1
参考文献	[1]. Zhang P, et al. Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model. J Pharmacol Exp Ther. 2015 Jan;352(1):139-47. [2]. Chen YY, et al. Demethyleneberberine alleviates inflammatory bowel disease in mice through regulating NF-κB signaling and T-helper cell homeostasis. Inflamm Res. 2017 Feb;66(2):187-196. [3]. Qiang X, et al. Demethyleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress. Biochem Biophys Res Commun. 2016 Apr 15;472(4):603-9.

分子式	C₁₉H₁₈NO₄+
分子量	323.34300
精确质量	323.11600
PSA	59.64000
LogP	1.64990

盐酸小檗碱

633-65-8

~43%

去亚甲基小檗碱

25459-91-0

文献：XINTRIA PHARMACEUTICAL CORPORATION, INC.; LIPPA, Arnold, Stan Patent: WO2010/104595 A1, 2010 ; Location in patent: Page/Page column 103 ;

2-(3,4-二羟基苯基)乙胺

51-61-6

去亚甲基小檗碱

25459-91-0

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1380 – 1383

2,3-二甲氧基苯甲醛

86-51-1

去亚甲基小檗碱

25459-91-0

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1380 – 1383

去亚甲基小檗碱上游产品? 3
CAS号633-65-8 盐酸小檗碱 CAS号51-61-6 2-(3,4-二羟基苯基)乙胺 CAS号86-51-1 2,3-二甲氧基苯甲醛
去亚甲基小檗碱下游产品? 0

去亚甲基小檗碱上游产品? 3

CAS号633-65-8
盐酸小檗碱

CAS号51-61-6
2-(3,4-二羟基苯基)乙胺

CAS号86-51-1
2,3-二甲氧基苯甲醛

去亚甲基小檗碱下游产品? 0

demethyleneberberine

2,3-Dihydroxy-9,10-dimethoxy-7,8,13,14-tetradehydro-berbinium

2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium

7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-dihydroxy-berbinium

2,3-dihydroxy-9,10-dimethoxy-5,6-dihydro-isoquino[3,2-a]isoquinolinylium

Demethylen-berberin

Dibenzo[a,g]quinolizinium,5,6-dihydro-2,3-dihydroxy-9,10-dimethoxy

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去亚甲基小檗碱

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