去甲氧基醉椒素

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3-氨基环丁醇盐酸盐
(3-(Benzyloxy)phenyl)methanamine hydrochloride

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中文名	去甲氧基醉椒素
英文名	Desmethoxy Yangonin
中文别名	(E)-4-甲氧基-6-苯乙烯基-2H-吡喃-2-酮 \| 卡文内酯
英文别名	更多

描述

去甲氧基醉椒素(Desmethoxyyangonin)是MAO-B可逆性抑制剂。

相关类别

信号通路 >>

神经信号通路 >>

单胺氧化酶

研究领域 >>

其他

天然产物 >>

其他

溶解度

体外：

在DMSO中10mM

储备液

1 mM	4.3814 mL	21.9068 mL	43.8135 mL
5 mM	0.8763 mL	4.3814 mL	8.7627 mL
10 mM	0.4381 mL	2.1907 mL	4.3814 mL

存储

粉末	-20℃下	3年
	4℃下	2年
在溶剂中	-80℃下	6个月
	-20℃下	1个月

运输

室温;可能会有所不同

SMILES

O=C1C=C(OC)C=C(/C=C/C2=CC=CC=C2)O1

参考文献

[1]. Uebelhack R, et al. Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). Pharmacopsychiatry. 1998 Sep;31(5):187-92.

[2]. Baum SS, et al. Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Oct;22(7):1105-20.

[3]. Ma Y, et al. Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. Drug Metab Dispos. 2004 Nov;32(11):1317-24.

相关活性
小分子

密度	1.2±0.1 g/cm3
沸点	440.0±45.0 °C at 760 mmHg
熔点	138-140?C
分子式	C₁₄H₁₂O₃
分子量	228.243
闪点	188.0±23.3 °C
精确质量	228.078644
PSA	39.44000
LogP	1.80
外观性状	白色至淡的黄色粉末
蒸汽压	0.0±1.1 mmHg at 25°C
折射率	1.588
储存条件	2-8°C

去甲氧基醉椒素毒性英文版

危险品运输编码	NONH for all modes of transport

Fatal kavalactone intoxication by suicidal intravenous injection.

Forensic Sci. Int. 249 , e7-11, (2015)

Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxioly…

Contribution to the quantitative and enantioselective determination of kavapyrones by high-performance liquid chromatography on ChiraSpher NT material.

J. Chromatogr. B. Biomed. Sci. Appl. 702(1-2) , 240-4, (1997)

A simultaneous HPLC separation of the enantiomers of kavain, dihydrokavain, methysticin and dihydromethysticin, as well as the achiral dienolides yangonin and desmethoxyyangonin was carried out on a C…

[Effects of the constituents of Alpinia speciosa rhizoma on experimental ulcers].

Taiwan Yi Xue Hui Za Zhi. 86(1) , 58-64, (1987)

DIHYDROKAVAIN

2H-Pyran-2-one, 4-methoxy-6-(2-phenylethenyl)-

2H-Pyran-2-one, 4-methoxy-6-[(E)-2-phenylethenyl]-

4-Methoxy-6-[(E)-2-phenylvinyl]-2H-pyran-2-one

4-methoxy-6-[(E)-2-phenylethenyl]-2H-pyran-2-one

Desmethoxyyangonin

(E)-4-Methoxy-6-(2-phenylethenyl)-2H-pyran-2-one,5,6-Dehydrokavain,Demethoxyyangonin

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去甲氧基醉椒素

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