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双去甲氧基姜黄素

双去甲氧基姜黄素

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?双去甲氧基姜黄素名称


















中文名

双去甲氧基姜黄素
英文名

Bisdemethoxycurcumin
中文别名


双去氧基姜黄素




|



姜黄素III



英文别名
更多





?双去甲氧基姜黄素生物活性












































描述
双去甲氧基姜黄素(Bisdemethoxycurcumin)是姜黄素衍生物,具有抗炎症和抗癌活性。
相关类别





溶解度

体外:

DMSO:≥31mg / mL(100.54 mM)

* “≥”表示可溶,但饱和度未知。


储备液

1 mM 3.2433 mL 16.2164 mL 32.4328 mL
5 mM 0.6487 mL 3.2433 mL 6.4866 mL
10 mM 0.3243 mL 1.6216 mL 3.2433 mL


存储

粉末 -20℃下 3年
4℃下 2年
在溶剂中 -80℃下 6个月
-20℃下 1个月


运输

室温;可能会有所不同
SMILES

O=C(CC(/C=C/C1=CC=C(O)C=C1)=O)/C=C/C2=CC=C(O)C=C2.[E].[E]
参考文献

[1]. Lee PJ, et al. Bisdemethoxycurcumin Induces Apoptosis in Activated Hepatic Stellate Cells via Cannabinoid Receptor 2. Molecules. 2015 Jan 14;20(1):1277-92.

[2]. Chen J, et al. Natural borneol enhances bisdemethoxycurcumin-induced cell cycle arrest in the G2/M phase through up-regulation of intracellular ROS in HepG2 cells. Food Funct. 2014 Dec 24.

[3]. Luo C, et al. Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction. Oncol Lett. 2015 Jan;9(1):270-274.

[4]. Li YB, et al. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med. 2013;2013:851714.


相关活性
小分子




天丰素



|

伊利司莫



|

Adarotene



|

杨梅素



|

血根碱



|

白桦脂酸



|

牛磺鹅去氧胆酸



|

宝藿苷 I



|

木香烃内酯



|

(20S)人参皂苷 Rh2



|

桦木醇



|

虎杖苷



|

N1-(4-丁基-2-甲基苯基)乙酰胺



|

遍在蛋白异肽酶抑制剂I,G5



|

[6]-姜酚






?双去甲氧基姜黄素物理化学性质





































密度 1.3±0.1 g/cm3
沸点 551.3±45.0 °C at 760 mmHg
熔点 221-223?C
分子式 C19H16O4
分子量 308.328
闪点 301.3±25.2 °C
精确质量 308.104858
PSA 74.60000
LogP 3.39
蒸汽压 0.0±1.5 mmHg at 25°C
折射率 1.680






?双去甲氧基姜黄素安全信息
















危险品运输编码 NONH for all modes of transport














?双去甲氧基姜黄素文献18

更多文献














An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.

J. Nat. Prod. 73 , 1193-5, (2010)

Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple fo…





Molecularly imprinted polymers for cleanup and selective extraction of curcuminoids in medicinal herbal extracts.

Anal. Bioanal. Chem 407(3) , 803-12, (2015)

This paper describes the synthesis of novel molecularly imprinted polymers (MIPs), prepared by a noncovalent imprinting approach, for cleanup and preconcentration of curcumin (CUR) and bisdemethoxycur…





Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity.

Eur. J. Med. Chem. 45 , 4446-57, (2010)

Curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin (3), the curcuminoid constituents of the medicinal plant Curcuma longa L., have been structurally modified to 55 analogs and antimycobacter…









?双去甲氧基姜黄素英文别名






























1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (E,E)-


bis(4-hydroxycinnamoyl)methane


Bis(p-hydroxycinnamoyl)methane


Bisdemethoxycurcumin


(1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione


(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione


1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (1E,6E)-








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