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地索奈德

地索奈德

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?地索奈德名称
















中文名

地索奈德
英文名

desonide
英文别名
更多





?地索奈德生物活性












































描述
Desonide是非氟化皮质类固醇抗炎剂，能作用于糖皮质激素受体。
相关类别



溶解度

体外：

在DMSO中10mM


储备液

1 mM 2.4009 mL 12.0045 mL 24.0090 mL
5 mM 0.4802 mL 2.4009 mL 4.8018 mL
10 mM 0.2401 mL 1.2005 mL 2.4009 mL


存储

粉末 -20℃下 3年
4℃下 2年
在溶剂中 -80℃下 6个月
-20℃下 1个月


运输

室温;可能会有所不同
SMILES

C[C@@]12[C@@]3(C(CO)=O)[C@@](OC(C)(O3)C)([H])C[C@@]1([H])[C@]4([H])CCC5=CC(C=C[C@]5(C)[C@@]4([H])[C@@H](O)C2)=O
参考文献

[1]. Kahanek, N., C. Gelbard, and A. Hebert, Desonide: a review of formulations, efficacy and safety. Expert Opin Investig Drugs, 2008. 17(7): p. 1097-104.

[2]. Castanedo-Cazares, J.P., et al., Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. Clin Cosmet Investig Dermatol, 2013. 6: p. 29-36.

[3]. Parish, D. and N. Scheinfeld, Desonide foam: a review. Drugs Today (Barc), 2008. 44(1): p. 55-62.
相关活性
小分子



氢化可的松



|

米非司酮



|

皮质酮



|

泼尼松



|

原人参三醇



|

氟替卡松丙酸酯



|

曲安西龙



|

可的松



|

AL 082D06



|

糖皮质激素受体激动剂



|

Mapracorat



|

环索奈德



|

丙酸倍氯米松



|

丙酸氯倍他索



|

Cort108297






?地索奈德物理化学性质











































密度 1.3±0.1 g/cm3
沸点 580.1±50.0 °C at 760 mmHg
熔点 274 – 275?C
分子式 C24H32O6
分子量 416.507
闪点 196.9±23.6 °C
精确质量 416.219879
PSA 93.06000
LogP 2.62
外观性状 固体;White to Almost white powder to crystal
蒸汽压 0.0±3.7 mmHg at 25°C
折射率 1.598
储存条件 Refrigerator





?地索奈德毒性和生态




地索奈德毒性英文版





?地索奈德安全信息


















危险品运输编码 NONH for all modes of transport
海关编码 2937210000





?地索奈德合成线路














16α-羟基泼尼松龙结构式

16α-羟基泼尼松龙

13951-70-7




~%







地索奈德结构式

地索奈德

638-94-8


文献：Journal of the American Chemical Society, , vol. 81, p. 4573







?地索奈德上下游产品













地索奈德上游产品? 1

地索奈德下游产品? 2










?地索奈德海关









海关编码 2937210000










?地索奈德英文别名


























































































Prednacinolone


(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one


16a,17a-Isopropylidenedioxyprednisolone


2H-naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-


Desowen


2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(2-hydroxyacetyl)-4a,6a,8,8-tetramethyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-


Locapred


Desonide


(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacétyl)-4a,6a,8,8-tétraméthyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodécahydro-2H-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-2-one


Sterax


11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-Acetal with Acetone


16a-Hydroxy-D1-hydrocortisone-16a,17a-acetonide


16a-Hydroxyprednisolone-16a,17-acetonide


Steroderm


16a-Hydroxyprednisolone Acetonide


TRIDESILON


desonidum [INN_la]


MFCD00866151


11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone


(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-Hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-on


(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-6b-Glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one


11b,21-Dihydroxy-16a,17-isopropylidenedioxy-1,4-pregnadiene-3,20-dione


Topifug


d-2083


EINECS 211-351-6


11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione


Budesonide Impurity 6








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