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| 描述 |
Epibrassinolide 是一种天然油菜素类固醇(BR)衍生物，是一种植物调节剂，具有与哺乳动物类固醇相似的结构。Epibrassinolide在各种癌细胞中是一种潜在的凋亡诱导剂，而不影响非肿瘤细胞生长。 |
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| 相关类别 |
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| 靶点 |
Plant growth regulator, Apoptosis inducer[1]
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| 体外研究 |
表油菜素内酯（EBR）是油菜素类固醇，类固醇衍生植物生长调节剂家族的生物活性化合物。将细胞与各种剂量（0-100μM）的表油菜素内酯一起温育24或48小时，并通过MTT测定法测定细胞活力。与LNCaP和DU145前列腺癌细胞中的未处理样品相比，表油菜素内酯以剂量和时间依赖性方式诱导细胞活力丧失。与DU145细胞相比，增加浓度的表油菜素内酯对LNCaP细胞活力丧失更有效，这表明雄激素依赖性细胞对表油菜素内酯比对雄激素非依赖性前列腺癌细胞更敏感。在进一步的实验中，选择25μM的表油菜素内酯，因为其对两种细胞系具有中等的细胞毒性作用。通过在96小时内计数细胞数来检查表油菜素内酯治疗对细胞增殖的影响。在LNCaP中观察到比DU145细胞更高和更早的细胞增殖抑制[1]。 |
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| 溶解度 |
体外：
DMSO：≥5mg / mL（10.40 mM） * “≥”表示可溶，但饱和度未知。
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| 储备液 |
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| 细胞实验 |
使用LNCaP（CRL-1740）和DU145（CRL-2698）人前列腺癌细胞系。使用PNT1a正常前列腺上皮细胞系。细胞在RPMI 1640培养基中生长，补充有10％胎牛血清，10,000U青霉素/ mL和10mg链霉素/ mL。将细胞在37℃下在潮湿的5％CO 2培养箱（HERA细胞150）中培养。将细胞接种过夜，然后用所需的药物浓度处理。将细胞以每孔1×104密度接种于96孔板中，并暴露于各种浓度的表油菜素内酯24和48小时。向每个孔中加入10μLMTT染料（5mg / mL），并将细胞在37℃下保持4小时。将得到的甲crystals晶体溶解在200μLDMSO中。用分光光度法在570nm处读取溶解的甲amount的密度[1]。 |
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| 存储 |
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| 运输 |
室温;可能会有所不同 |
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| SMILES |
C[C@@]1([C@@]2([H])[C@H](C)[C@@H](O)[C@H](O)[C@H](C)C(C)C)[C@](CC2)([H])[C@@](COC3=O)([H])[C@]([C@@]4([C@]3([H])C[C@H](O)[C@H](O)C4)C)([H])CC1 |
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| 参考文献 |
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| 相关活性 小分子 |
伊利司莫 | Adarotene | 杨梅素 | 血根碱 | 白桦脂酸 | 牛磺鹅去氧胆酸 | 宝藿苷 I | 木香烃内酯 | (20S)人参皂苷 Rh2 | 桦木醇 | 虎杖苷 | N1-(4-丁基-2-甲基苯基)乙酰胺 | 遍在蛋白异肽酶抑制剂I,G5 | [6]-姜酚 | 甘氨鹅脱氧胆酸-[D9] |
| 密度 | 1.1±0.1 g/cm3 |
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| 沸点 | 633.7±55.0 °C at 760 mmHg |
| 熔点 | 256°C |
| 分子式 | C28H48O6 |
| 分子量 | 480.677 |
| 闪点 | 202.3±25.0 °C |
| 精确质量 | 480.345093 |
| PSA | 107.22000 |
| LogP | 3.12 |
| 蒸汽压 | 0.0±4.2 mmHg at 25°C |
| 折射率 | 1.536 |
| 储存条件 | ?20°C |
| 个人防护装备 |
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| 风险声明 (欧洲) |
22-36/37/38 |
| 安全声明 (欧洲) |
22-36/37/39-45 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
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Organ-specific effects of brassinosteroids on stomatal production coordinate with the action of Too Many Mouths. J. Integr. Plant Biol. 57(3) , 247-55, (2015)
In Arabidopsis, stomatal development initiates after protodermal cells acquire stomatal lineage cell fate. Stomata or their precursors communicate with their neighbor epidermal cells to ensure the “on…
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Conifer somatic embryogenesis: improvements by supplementation of medium with oxidation-reduction agents. Tree Physiol. 35 , 209-24, (2015)
A major barrier to the commercialization of somatic embryogenesis technology in loblolly pine (Pinus taeda L.) is recalcitrance of some high-value crosses to initiate embryogenic tissue (ET) and conti…
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Proteomic Analysis of Microtubule Interacting Proteins over the Course of Xylem Tracheary Element Formation in Arabidopsis. Plant Cell 27 , 2709-26, (2015)
Plant vascular cells, or tracheary elements (TEs), rely on circumferential secondary cell wall thickenings to maintain sap flow. The patterns in which TE thickenings are organized vary according to th…
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CH09964 EPIBRASSINOLIDE |
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(1S,2R,3R,4S)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-5,6-dihydroxy-7a,9a-dimethyl-3H-benzo[c]indeno[5,4-e]oxepin-3-one |
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1,6-Dioxacyclodeca-3,8-dien |
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(1R,3aS,3bS,6aS,8S,9R,10aR,10bS,12aS)-1-[(1S,2R,3R,4S)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-8,9-dihydroxy-10a,12a-dimethyl-6H-benz[c]indeno[5,4-e]oxepin-6-one |
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24-Epicastasterone |
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3.24-EPIBRASSINOLIDE |
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5R)-3,4-Dihydroxy-5,6-dimethyl-2-heptanyl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one |
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(2a,3a,5a,22R,23R,24S)-2,3,22,23-Tetrahydroxy-B-homo-7-oxaergostan-6-one |
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5S)-3,4-Dihydroxy-5,6-dimethylheptan-2-yl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one |
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EPI BRASSINOLIDE |
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24-EPIBRASSINOLIDE |
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2α,3α,22,23-tetrahydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one |
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cis,cis-1,6-Dioxa-3,8-cyclodecadien |
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1,6-dioxa-cyclodeca-3,8-diene |
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4-Epicastasterone |
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5S)-3,4-Dihydroxy-5,6-dimethyl-2-heptanyl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one |
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5S)-3,4-Dihydroxy-5,6-dimethylheptan-2-yl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-on |
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(2α,3α,5α,22R,23R,24S)-2,3,22,23-Tetrahydroxy-B-homo-7-oxaergostan-6-one |
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2a,3a,22,23-Tetrahydroxy-24-methyl-B-homo-7-oxa-5a-cholestan-6-one |
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Epibrassinolide(24-Epibrassinolide) |
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Brassinolide(epibrassinolide,Homobrassinolide) |
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BRASSINOLIDE(BR) |
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2,4-Epibrassinolide |
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3H-Benz[c]indeno[5,4-e]oxepin-3-one, 10-[(1S,2R,3R,4S)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-5,6-dihydroxy-7a,9a-dimethyl-, (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)- |
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3H-Benz[c]indeno[5,4-e]oxepin-3-one, 10-[(1S,2R,3R,4R)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-5,6-dihydroxy-7a,9a-dimethyl-, (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)- |
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.(22R,23R,24R)-2 |
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Brassinolide |
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Epibrassinolide |
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24-(R)-EPIBRASSINOLIDE |
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brassinosteroid |
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