夫西地酸

中文名	夫西地酸
英文名	fusidic acid
中文别名	褐霉酸
英文别名	更多

描述	Fusidic acid (Fusidate) 是一种抑菌抗生素。
相关类别	研究领域 >> 感染信号通路 >> 抗感染 >> 细菌
靶点	Bacterial[1][2][3]
SMILES	C[C@@H]([C@]1([H])CC[C@]([C@@](C[C@@H]/2OC(C)=O)3C)4C)[C@H](O)CC[C@]1(C)[C@]4([H])[C@H](O)C[C@@]3([H])C2=C(C(O)=O)/CC/C=C(C)C
参考文献	[1]. Falagas ME, et al. Potential of old-generation antibiotics to address current need for new antibiotics. Expert Rev Anti Infect Ther. 2008 Oct;6(5):593-600. [2]. Leclercq R, et al. In vitro activity of fusidic acid against streptococci isolated from skin and soft tissue infections. J Antimicrob Chemother. 2000 Jan;45(1):27-9. [3]. Spelman D, et al. Fusidic acid in skin and soft tissue infections. Int J Antimicrob Agents. 1999 Aug;12 Suppl 2:S59-66.

密度	1.2±0.1 g/cm3
沸点	635.6±55.0 °C at 760 mmHg
熔点	190-192?C
分子式	C₃₁H₄₈O₆
分子量	516.709
闪点	197.7±25.0 °C
精确质量	516.345093
PSA	104.06000
LogP	6.41
外观性状	白色固体
蒸汽压	0.0±4.2 mmHg at 25°C
折射率	1.558
储存条件	2-8°C
水溶解性	水溶性：实际上不溶；可溶于：氯仿,醇,丙酮,二噁烷；极微溶：乙醚

夫西地酸毒性英文版

符号	GHS07
信号词	Warning
危害声明	H302
警示性声明	P301 + P312 + P330
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xn
风险声明 (欧洲)	R22
安全声明 (欧洲)	36
危险品运输编码	NONH for all modes of transport
RTECS号	RC1350000
海关编码	2942000000

海关编码	2942000000

Antibiotic exposure in a low-income country: screening urine samples for presence of antibiotics and antibiotic resistance in coagulase negative staphylococcal contaminants.

PLoS ONE 9(12) , e113055, (2014)

Development of antimicrobial resistance has been assigned to excess and misuse of antimicrobial agents. Staphylococci are part of the normal flora but are also potential pathogens that have become ess…

Multiple roles for Enterococcus faecalis glycosyltransferases in biofilm-associated antibiotic resistance, cell envelope integrity, and conjugative transfer.

Antimicrob. Agents Chemother. 59 , 4094-105, (2015)

The emergence of multidrug-resistant bacteria and the limited availability of new antibiotics are of increasing clinical concern. A compounding factor is the ability of microorganisms to form biofilms…

Enterococcus faecalis 6-phosphogluconolactonase is required for both commensal and pathogenic interactions with Manduca sexta.

Infect. Immun. 83(1) , 396-404, (2014)

Enterococcus faecalis is a commensal and pathogen of humans and insects. In Manduca sexta, E. faecalis is an infrequent member of the commensal gut community, but its translocation to the hemocoel res…

(2Z)-2-[(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoic acid

Fucidic acid

Fusidate sodium

EINECS 230-256-0

fusidic acid

Fusidin

FUCIDIN

(2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid

(2Z)-2-[(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoic acid

Fusidate

5-Heptenoic acid, 2-[(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methyl-, (2Z)-

Ramycin

fusdic acid

(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-Acetoxy-3,11-dihydroxy-4,8,14-trimethyl-18-norcholesta-17,24-dien-21-oic acid

Fucithalmic

Fucidin acid

MFCD00865135

3,11,16-Trihydroxy-4,8,10,14-tetramethyl-17-(1′-carboxyisohept-4′-enylidene)cyclopentanoperhydrophenanthrene 16-Acetate

FusidicAcid

29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3α,4α,8α,9β,11α,13α,14β,16β,17Z)-

(3a,4a,8a,9b,11a,13a,14b,16b,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic Acid

Diethanolamine fusidate

Fusidine

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夫西地酸名称

夫西地酸生物活性

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夫西地酸毒性和生态

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夫西地酸文献60

夫西地酸英文别名

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