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头孢美唑钠

头孢美唑钠

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?头孢美唑钠名称


















中文名

头孢美唑钠
英文名

cefmetazole sodium
中文别名


(6R,7S)-7-[[2-(氰甲基硫)乙酰]氨基]-7-甲氧基-3-[(1-甲基四唑-5-基)硫甲基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸钠盐



英文别名
更多





?头孢美唑钠生物活性












































描述
Cefmetazole钠是一种半合成的广谱头孢菌素类抗菌剂。
相关类别



溶解度

体外:

DMSO:≥39mg / mL(79.02 mM)

* “≥”表示可溶,但饱和度未知。


储备液

1 mM 2.0263 mL 10.1313 mL 20.2626 mL
5 mM 0.4053 mL 2.0263 mL 4.0525 mL
10 mM 0.2026 mL 1.0131 mL 2.0263 mL


存储

4°C,避光


运输

室温;可能会有所不同
SMILES

O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@](OC)(NC(CSCC#N)=O)C1=O)[O-].[Na+]
参考文献

[1]. Schentag JJ, et al. Cefmetazole sodium: pharmacology, pharmacokinetics, and clinical trials. Pharmacotherapy. 1991;11(1):2-19.


相关活性
小分子




嘌呤霉素盐酸盐



|

G-418 硫酸盐



|

衣霉素



|

潮霉素B



|

盐霉素



|

阿维巴坦钠



|

硫酸新霉素



|

法硼巴坦



|

甲氧西林钠



|

利福平



|

甲硝唑



|

羧苄青霉素钠



|

头孢他啶



|

Eravacycline dihydrochloride



|

头孢噻肟钠






?头孢美唑钠物理化学性质































密度 1.75 g/cm3
分子式 C15H16N7NaO5S3
分子量 493.516
精确质量 493.027283
PSA 242.06000
外观性状 白色固体
储存条件 库房低温通风干燥
水溶解性 水溶性:完全溶解;易溶于:甲醇;可溶于:丙酮;极微溶:乙醇;不溶:氯仿,四氢呋喃





?头孢美唑钠毒性和生态




头孢美唑钠毒性英文版






?头孢美唑钠安全信息



































符号

GHS07

GHS08


GHS07, GHS08
信号词
Danger
危害声明
H315-H317-H319-H334-H335
警示性声明
P261-P280-P305 + P351 + P338-P342 + P311
危害码 (欧洲)
Xi:Irritant;
风险声明 (欧洲)
R36/37/38;R42/43
安全声明 (欧洲)
S26-S36
危险品运输编码 NONH for all modes of transport
WGK德国 2
RTECS号 XI0372200














?头孢美唑钠文献29

更多文献














Chimeric mice with humanized liver.

Toxicology 246(1) , 9-17, (2008)

Recently, chimeric mice with humanized liver were established by transplanting human hepatocytes into an urokinase-type plasminogen activator(+/+)/severe combined immunodeficient transgenic mouse line…





Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery

Asian J. Surg. 35(2) , 81-7, (2012)

Objective We retrospectively evaluated the usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery.





Involvement of multidrug resistance-associated protein 4 in efflux transport of prostaglandin E(2) across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins.

J. Pharmacol. Exp. Ther. 333 , 912-919, (2010)

Prostaglandin E(2) (PGE(2)) acts as a modulator of synaptic signaling and excitability in the brain. Because PGE(2) is barely inactivated enzymatically in adult brain, its brain level is considered to…









?头孢美唑钠英文别名






























5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-[(cyanomethyl)thio]acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, sodium salt, (6R,7S)- (1:1)


sodium,(6R,7S)-7-[[2-(cyanomethylsulfanyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate


Sodium (6R,7S)-7-(2-((Cyanomethyl)thio)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate


MFCD00865068


Cefmetazole Sodium Salt


Sodium (6R,7S)-7-({[(cyanomethyl)sulfanyl]acetyl}amino)-7-methoxy-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate


Cefmetazole (sodium)








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