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孕二烯二酮
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| 描述 |
（-）-（E）-古古尔甾酮是Z-古尔甾酮的代谢产物。Guggulsterone是guggulipid的一种活性成分，guggulipid是一种阿育吠陀药物，来源于Commiphora mukul。Guggulsterone具有降血脂活性[1]。 |
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| 相关类别 |
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| 存储 |
请将产品存放在分析证书中的建议条件下。
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| 运输 |
室温 |
| 参考文献 |
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| 密度 | 1.1±0.1 g/cm3 |
|---|---|
| 沸点 | 463.3±45.0 °C at 760 mmHg |
| 熔点 | 170-171.5° |
| 分子式 | C21H28O2 |
| 分子量 | 312.446 |
| 闪点 | 172.3±25.7 °C |
| 精确质量 | 312.208923 |
| PSA | 34.14000 |
| LogP | 3.65 |
| 蒸汽压 | 0.0±1.1 mmHg at 25°C |
| 折射率 | 1.557 |
| 符号 |
GHS07 |
|---|---|
| 信号词 |
Warning |
| 危害声明 |
H335 |
| 警示性声明 |
P261 |
| 危害码 (欧洲) |
Xi |
| 风险声明 (欧洲) |
37-52/53 |
| 安全声明 (欧洲) |
61-36 |
| 危险品运输编码 | NONH for all modes of transport |
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Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone. Biochim. Biophys. Acta 1844(9) , 1684-93, (2014)
Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative…
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Guggulsterone attenuates cerulein-induced acute pancreatitis via inhibition of ERK and JNK activation. Int. Immunopharmacol. 26 , 194-202, (2015)
Guggulsterone (GS), a plant steroid and a compound found at high levels in Commiphora myrrha, exhibits anti-inflammatory, anti-cancer, and cholesterol-lowering effects. However, the potential of GS to…
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CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol. Pharmacol. 87(5) , 878-89, (2015)
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that enhance the detoxification and elimination of xenobiotics and endobiotics by modulating the expression …
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Z-guggulsterone |
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UNII:9B259YE66O |
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E-guggulsterone |
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Pregna-4,17-diene-3,16-dione, (17E)- |
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trans-Guggulsterone |
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Guggulsterone |
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(17E)-Pregna-4,17-diene-3,16-dione |
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Pregna-4,17(20)-diene-3,16-dione, (17E)- |
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(17E)-Pregna-4,17(20)-diene-3,16-dione |
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GUGGULSTERONE E |
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GS,TRANS |
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GUGGULESTERONE E |
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GUGGULSTERONE, (E)- |
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Z-Guggulsteron |
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