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山奈酚-3-O-β-D-槐糖苷

山奈酚-3-O-β-D-槐糖苷

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?山奈酚-3-O-β-D-槐糖苷名称


















中文名

山奈酚-3-O-β-D-槐糖苷
英文名

kaempferol 3-O-β-D-glucosyl-(1→2)-β-D-glucoside
中文别名


山奈酚-3-O-Beta-D-槐糖苷




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山奈酚-3-O-Beta-D-槐糖苷,山奈酚-3-O-槐糖苷



英文别名
更多





?山奈酚-3-O-β-D-槐糖苷生物活性




































描述
Kaempferol 3-O-sophoroside,Kaempferol 的衍生物,分离于栽培山参 (Panax ginseng) 的叶子,具有抗炎活性。
相关类别



靶点

Kaempferol 3-O-sophoroside possesses barrier integrity activity, inhibitory activity on cell adhesion and migration to endothelial cells by blocking the activation of NF-κB expression and production of TNF-α, thereby endorsing its usefulness as therapy for vascular inflammatory diseases[1].


SMILES

O=C1C(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)=C(C4=CC=C(O)C=C4)OC5=CC(O)=CC(O)=C15
参考文献

[1]. Kim TH, et al. Anti-inflammatory effects of kaempferol-3-O-sophoroside in human endothelial cells. Inflamm Res. 2012 Mar;61(3):217-24.







?山奈酚-3-O-β-D-槐糖苷物理化学性质





































密度 1.8±0.1 g/cm3
沸点 995.0±65.0 °C at 760 mmHg
熔点 194-198℃
分子式 C27H30O16
分子量 610.518
闪点 329.3±27.8 °C
精确质量 610.153381
PSA 269.43000
LogP -0.58
蒸汽压 0.0±0.3 mmHg at 25°C
折射率 1.764





?山奈酚-3-O-β-D-槐糖苷毒性和生态




山奈酚-3-O-β-D-槐糖苷毒性英文版





?山奈酚-3-O-β-D-槐糖苷合成线路




















~49%







山奈酚-3-O-β-D-槐糖苷结构式

山奈酚-3-O-β-D-槐糖苷

19895-95-5






文献:Markham, Kenneth R.; Andersen, Oeyvind M. Phytochemistry (Elsevier), 1990 , vol. 29, # 12 p. 3919 – 3920





~%







山奈酚-3-O-β-D-槐糖苷结构式

山奈酚-3-O-β-D-槐糖苷

19895-95-5






文献:Yoshida; Saito; Kadoya Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 1 p. 97 – 107





~%







山奈酚-3-O-β-D-槐糖苷结构式

山奈酚-3-O-β-D-槐糖苷

19895-95-5






文献:Chemical and Pharmaceutical Bulletin, , vol. 35, # 1 p. 97 – 107







?山奈酚-3-O-β-D-槐糖苷上下游产品













山奈酚-3-O-β-D-槐糖苷上游产品? 1

山奈酚-3-O-β-D-槐糖苷下游产品? 1















?山奈酚-3-O-β-D-槐糖苷英文别名

































5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside


Kaempferol-3-sophoroside


4H-1-Benzopyran-4-one, 3-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-


Kaempferol 3-O-sophoroside


Sophoraflavonoloside


K3S


3-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one


kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside








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