布地奈德

中文名	左布地奈德
英文名	budesonide
中文别名	16alpha,17alpha-22R,S-丙基亚甲基二氧-孕甾-1,4-二烯-11beta,21-二羟基-3,20二酮
英文别名	更多

描述

Budesonide是一种具有强效抗炎活性的糖皮质类固醇。

相关类别

信号通路 >>

G 蛋白偶联受体/G 蛋白 >>

糖皮质激素受体

研究领域 >>

代谢疾病

溶解度

体外：

DMSO：215 mg / mL（499.38 mM;需要超声波和加热）

储备液

1 mM	2.3227 mL	11.6136 mL	23.2272 mL
5 mM	0.4645 mL	2.3227 mL	4.6454 mL
10 mM	0.2323 mL	1.1614 mL	2.3227 mL

存储

粉末	-20℃下	3年
	4℃下	2年
在溶剂中	-80℃下	6个月
	-20℃下	1个月

运输

室温;可能会有所不同

SMILES

O=C(C=C[C@@]12C)C=C1CC[C@@]([C@]2([H])[C@@H](O)C[C@@]34C)([H])[C@]3([H])C[C@]5([H])[C@@]4(C(CO)=O)OC(CCC)O5

参考文献

[1]. Lichtenstein, G.R., et al., Management of Crohn’s disease in adults. Am J Gastroenterol, 2009. 104(2): p. 465-83; quiz 464, 484.

[2]. Habal, F.M. and V.W. Huang, Review article: a decision-making algorithm for the management of pregnancy in the inflammatory bowel disease patient. Aliment Pharmacol Ther, 2012. 35(5): p. 501-15.

[3]. Todd, G.R., et al., Survey of adrenal crisis associated with inhaled corticosteroids in the United Kingdom. Arch Dis Child, 2002. 87(6): p. 457-61.

相关活性
小分子

密度	1.3±0.1 g/cm3
沸点	599.7±50.0 °C at 760 mmHg
熔点	221-232?C (dec.)
分子式	C₂₅H₃₄O₆
分子量	430.534
闪点	201.8±23.6 °C
精确质量	430.235535
PSA	93.06000
LogP	3.14
外观性状	白色固体
蒸汽压	0.0±3.9 mmHg at 25°C
折射率	1.592
储存条件	库房通风低温干燥

布地奈德MSDS英文版

布地奈德毒性英文版

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲)	Xn:Harmful
风险声明 (欧洲)	R40
安全声明 (欧洲)	S22-S36
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	TU3723000
海关编码	29372900

海关编码	29372900

Processing of pharmaceutical materials by electrospraying under reduced pressure.

Drug Dev. Ind. Pharm. 41(1) , 116-23, (2014)

Electrospraying was used in drug particle production.The aim of the research was to evaluate the possibilities to produce drug particles with desired pharmaceutical properties by electrospraying. In p…

In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383.

Pharm. Res. 32 , 3937-51, (2015)

To assess accumulation and lysosomal sequestration of 9 drugs used in respiratory indications (plus imipramine as positive control) in the alveolar macrophage (AM) cell line NR8383.For all drugs, upta…

Bsm1 vitamin D receptor polymorphism and calcium homeostasis following bariatric surgery.

J. Invest. Surg. 28(1) , 8-17, (2015)

To evaluate the association between the Bsm1 vitamin D receptor polymorphism and the calcium-vitamin D-parathormone axis following bariatric surgery.This cross-sectional study included 86 morbidly obe…

Budesonide

Respules

Spirocort

Bidien

2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(2-hydroxyacetyl)-4a,6a-dimethyl-8-propyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-

Budesonide,(11β,16α)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione

S-1320

16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione

EINECS 257-139-7

Budeson

Micronyl

Pulmicort

MFCD00083259

ENTOCORT

Rhinocort

(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-6b-Glycoloyl-5-hydroxy-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

2H-naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-

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布地奈德MSDS

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