异欧前胡素

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中文名	异欧前胡素
英文名	isoimperatorin
中文别名	4-(3-甲基丁-2-烯氧基)呋喃并[3,2-g]苯并吡喃-7-酮 \| 4-(3-甲基丁-2-烯氧基)呋喃并[3,2-g]苯并吡喃-7-酮 \| 白芷甲素
英文别名	更多

描述

Isoimperatorin 是Angelica dahurica 根的甲醇提取物，有效抑制乙酰胆碱酯酶 (AChE)，IC50 为 74.6 μM。

相关类别

信号通路 >>

神经信号通路 >>

疼痛

天然产物 >>

苯丙酸类

研究领域 >>

神经疾病

靶点

IC50: 74.6 μM (AChE)[1]

体外研究

在针对中草药新农药的筛选计划中，发现羌活根茎的乙醇提取物对两种线虫，松材线虫和南方根结线虫具有强烈的杀线虫活性。基于生物活性引导的分级分离，从乙醇提取物中分离出四种成分，并鉴定为Columbianetin，Falcarindiol，Falcarinol和Isoimperatorin。异欧前胡素对B. xylophilus的LC50值为21.83μg/ mL。当使用15分钟的紫外线光照处理时，镰刀菌醇，镰刀菌素和异欧前胡素对南方根结线虫的毒性几乎是黑暗处理的5倍，而哥伦比亚的毒性仅为毒性的2倍。已经证明异欧前胡素具有对几种昆虫的杀虫活性，如卷心菜蚜虫（Brevicoryne brassicae）[2]。在白芷（AD）提取物的活性部分中鉴定出异欧前胡素[3]。异欧前胡素通常用作内标（IS）[4]。

溶解度

体外：

在DMSO中10mM

储备液

1 mM	3.6999 mL	18.4993 mL	36.9987 mL
5 mM	0.7400 mL	3.6999 mL	7.3997 mL
10 mM	0.3700 mL	1.8499 mL	3.6999 mL

存储

请将产品存放在分析证书中的建议条件下。

运输

室温;可能会有所不同

SMILES

O=C1C=CC2=C(OC/C=C(C)/C)C3=C(OC=C3)C=C2O1

参考文献

[1]. Kim DK, et al. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch Pharm Res. 2002 Dec;25(6):856-9.

[2]. Liu G, et al. Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita. Molecules. 2016 Sep 23;21(10). pii: E1276.

[3]. Park EY, et al. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PLoS One. 2016 Jul 8;11(7):e0158796.

[4]. Yu XA, et al. The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J. 2016 Oct 14;10:62.

相关活性
小分子

密度	1.2±0.1 g/cm3
沸点	448.3±45.0 °C at 760 mmHg
熔点	109?C
分子式	C₁₆H₁₄O₄
分子量	270.280
闪点	224.9±28.7 °C
精确质量	270.089203
PSA	52.58000
LogP	3.88
外观性状	白色粉末
蒸汽压	0.0±1.1 mmHg at 25°C
折射率	1.606
储存条件	-20°C Freezer

危险品运输编码	NONH for all modes of transport
RTECS号	LV1513000

香柑醇

486-60-2

1-溴-3-甲基-2-丁烯

870-63-3

~75%

异欧前胡素

482-45-1

文献：Row; Brown; Stachulski; Lennard Organic and Biomolecular Chemistry, 2006 , vol. 4, # 8 p. 1604 – 1610

佛手柑内酯

484-20-8

异欧前胡素

482-45-1

文献：Row; Brown; Stachulski; Lennard Organic and Biomolecular Chemistry, 2006 , vol. 4, # 8 p. 1604 – 1610

异欧前胡素上游产品? 3
CAS号486-60-2 香柑醇 CAS号870-63-3 1-溴-3-甲基-2-丁烯 CAS号484-20-8 佛手柑内酯
异欧前胡素下游产品? 3
CAS号486-60-2 香柑醇 CAS号737-52-0 氧化前胡素 CAS号2643-85-8 水合氧化前胡素

异欧前胡素上游产品? 3

CAS号486-60-2
香柑醇

CAS号870-63-3
1-溴-3-甲基-2-丁烯

CAS号484-20-8
佛手柑内酯

异欧前胡素下游产品? 3

CAS号486-60-2
香柑醇

CAS号737-52-0
氧化前胡素

CAS号2643-85-8
水合氧化前胡素

In vitro activity of isoimperatorin, alone and in combination, against Mycobacterium tuberculosis.

Lett. Appl. Microbiol. 58(4) , 344-9, (2014)

Previous studies have shown that isoimperatorin (IO), a furanocoumarin isolated from several medicinal plants, has antimycobacterial activity against Mycobacterium tuberculosis strain H37Rv (ATCC 2729…

Study on pharmacokinetics and tissue distribution of pteryxin in mice by ultra-pressure liquid chromatography with tandem mass spectrometry.

Biomed. Chromatogr. 26(7) , 802-7, (2012)

Pteryxin is a coumarin compound naturally occurring in the roots of Radix Peucedani, a commonly used as traditional Chinese medicine for the treatment of certain respiratory diseases and hypertension….

Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2 and tumor necrosis factor-alphavia mitogen-activated protein kinases and nuclear factor-kappaB in macrophages.

Pharmacol. Res. 55(4) , 263-70, (2007)

Angelica dahurica (Umbelliferae) has been used to treat headache of common cold, supraorbital neuralgia, painful swelling on the body, nasal stuffiness, leukorrhea and arthralgia due to wind-dampness …

7H-Furo[3,2-g][1]benzopyran-7-one, 4-[(3-methyl-2-buten-1-yl)oxy]-

IisoiMperatorin

buten-1-yl)oxy]

7H-Furo[3,2-g][1]benzopyran-7-one, 4-[(3-methyl-2-butenyl)oxy]-

Iso Imperatorin

Isoimperatoin

MFCD00272155

4-[(3-Methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one

7H-Furo[3,2-g][1]benzopyran-7-one, 4-((3-methyl-2-butenyl)oxy)-

Isoimperatorin

4-PRENYLOXYPSORALEN

Isomperatorin

Auraptin

isoimperatonin

4-[(3-Methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one

7H-Furo(3,2-g)(1)benzopyran-7-one, 4-((3-methyl-2-butenyl)oxy)-

Cnidin

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异欧前胡素

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