描述 |
Erythromycin estolate 是红霉素衍生物,是一种大环内酯类抗生素,用于治疗多种细菌感染。Erythromycin estolate 引起数例肝损伤,主要包括胆汁淤积性肝炎。Erythromycin estolate 的毒性与其对胆汁酸运输的抑制作用有关。 |
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相关类别 |
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SMILES |
CCCCCCCCCCCCOS(=O)(O)=O.CCC(O[C@H]([C@H](C[C@@H](C)O1)N(C)C)[C@]1([H])O[C@@H]2[C@H]([C@@H]([C@H](C(O[C@@H]([C@@](C)(O)[C@H](O)[C@@H](C)C([C@H](C)C[C@]2(O)C)=O)CC)=O)C)O[C@@]3([H])C[C@](C)([C@@H](O)[C@H](C)O3)OC)C)=O |
参考文献 |
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密度 | 1.0053 (rough estimate) |
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沸点 | 827.7?C at 760 mmHg |
熔点 | 135-140?C dec. |
分子式 | C52H97NO18S |
分子量 | 1000.324 |
闪点 | 454.4?C |
精确质量 | 999.616394 |
PSA | 271.96000 |
LogP | 7.55400 |
外观性状 | 长针状 |
折射率 | 1.6550 (estimate) |
储存条件 | -20°C Freezer |
水溶解性 | chloroform: soluble4.0ML, clear, colorless (200 mg + 4.0 mL Chloroform) |
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无味红霉素毒性英文版
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符号 |
GHS07, GHS08 |
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信号词 |
Danger |
危害声明 |
H302-H317-H334 |
警示性声明 |
P261-P280-P342 + P311 |
危害码 (欧洲) |
Xn:Harmful |
风险声明 (欧洲) |
R22;R42/43 |
安全声明 (欧洲) |
S22-S36 |
危险品运输编码 | NONH for all modes of transport |
WGK德国 | 3 |
RTECS号 | KF5775000 |
海关编码 | 29419000 |
Protective effect of Livex, a herbal formulation against erythromycin estolate induced hepatotoxicity in rats. J. Ethnopharmacol. 57(3) , 161-7, (1997)
Livex, a compound herbal formulation, was investigated for its possible hepatoprotective effect in Wistar rats against erythromycin estolate induced toxicity. Oral administration of Livex significantl…
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Preparation and characterization of biodegradable poly(l-lactide)/poly(ethylene glycol) microcapsules containing erythromycin by emulsion solvent evaporation technique. J. Colloid. Interface Sci. 271(2) , 336-41, (2004)
In this work, the producing of a biodegradable poly(l-lactide) (PLA)/poly(ethylene glycol) (PEG) microcapsule by emulsion solvent evaporation method was investigated. The effect of PEG segments added …
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Pharmacokinetics of erythromycin estolate and erythromycin phosphate after intragastric administration to healthy foals. Am. J. Vet. Res. 61(8) , 914-9, (2000)
To determine pharmacokinetics and plasma concentrations of erythromycin and related compounds after intragastric administration of erythromycin phosphate and erythromycin estolate to healthy foals.11 …
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Erythromycin Estolate |
Erythromycin 2′-propionate dodecyl sulfate |
Erythromycin 2′-propionate dodecyl sulfate |
Dodecyl hydrogen sulfate – (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (1:1) |
Erythromycin 2-Propionate Dodecyl Sulfate |