普鲁宁

中文名	柚(苷)配基-7-O-葡糖苷
英文名	naringenin 7-O-β-D-glucoside
中文别名	樱桃甙 \| 樱桃苷 \| 樱桃甙,洋李甙
英文别名	更多

描述	Prunin 是有效的人肠道病毒 A71 (HEVA71) 抑制剂。Prunin 对蛋白酪氨酸磷酸酶 1B (PTP1B) 有较强的抑制作用，IC50 值为 5.5 μM。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶研究领域 >> 感染研究领域 >> 代谢疾病
体外研究	Prunin通过降低胰岛素抵抗HepG2细胞PTP1B的表达水平，对ONOO介导的酪氨酸硝化和葡萄糖摄取具有剂量依赖性抑制作用。Prunin对α-葡萄糖苷酶有明显的抑制作用，IC50为317±2.12μM[2]。
存储	请将产品存放在分析证书中的建议条件下。
运输	室温
SMILES	O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13
参考文献	[1]. Gunaseelan S, et al. Prunin suppresses viral IRES activity and is a potential candidate for treating enterovirus A71 infection. Sci Transl Med. 2019 Oct 30;11(516). pii: eaar5759. [2]. Jung HA, et al. Prunin is a highly potent flavonoid from Prunus davidiana stems that inhibits protein tyrosine phosphatase 1B and stimulates glucose uptake in insulin-resistant HepG2 cells. Arch Pharm Res. 2017 Jan;40(1):37-48.

密度	1.6±0.1 g/cm3
沸点	802.4±65.0 °C at 760 mmHg
熔点	222-224?C
分子式	C₂₁H₂₂O₁₀
分子量	434.393
闪点	284.6±27.8 °C
精确质量	434.121307
PSA	166.14000
LogP	0.82
蒸汽压	0.0±3.0 mmHg at 25°C
折射率	1.691
储存条件	?20°C

符号	GHS09
信号词	Warning
危害声明	H410
警示性声明	P273-P501
危害码 (欧洲)	N
风险声明 (欧洲)	22
安全声明 (欧洲)	22-45
危险品运输编码	UN 3077 9 / PGIII

A rapid method for the determination of naringin, prunin, and naringenin applied to the assay of naringinase.

Anal. Biochem. 134(2) , 393-7, (1983)

A naringinase assay capable of distinguishing between the content of naringin, prunin, and naringenin present in the incubation mixture, is described. The amount of these compounds can be estimated by…

Antihyperlipidemic effect of flavonoids from Prunus davidiana.

J. Nat. Prod. 54(1) , 218-24, (1991)

Blood lipid levels in rats with hyperlipidemia resulting from high-fat feeding were determined after ip administration of an MeOH extract of Prunus davidiana stems and its flavonoid components, (+)-ca…

Crystal structure of prunin-1, a major component of the almond (Prunus dulcis) allergen amandin.

J. Agric. Food Chem. 57(18) , 8643-51, (2009)

Seed storage proteins are accumulated during seed development and act as a reserve of nutrition for seed germination and young sprout growth. Plant seeds play an important role in human nutrition by p…

5-Hydroxy-2-(4-hydroxyphényl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromén-4-one

4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-

4′,5-DIHYDROXY-7-GLUCOSYLOXYFLAVANONE

5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromen-4-on

5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl-β-D-glucopyranoside

naringenin 7-O-beta-D-glucoside

5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl β-D-glucopyranoside

NARINGENIN-7-O-GLUCOSIDE

5-Hydroxy-2-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2,3-dihydro-4H-chromen-4-one

Naringenin-7-glucoside

PRUNIN

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