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| 描述 |
Trilostane(Win 24540; Modrastane)是3 β-羟化类固醇脱氢酶抑制剂，可作用于库兴氏综合征。 |
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| 相关类别 |
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| 溶解度 |
体外：
DMSO：≥56mg / mL（169.99 mM） * “≥”表示可溶，但饱和度未知。
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| 储备液 |
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| 存储 |
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| 运输 |
室温;可能会有所不同 |
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| SMILES |
OC1=C(C#N)C[C@@]2(C)[C@@]3(CC[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])CC[C@@H]5O)[C@@H]1O3 |
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| 参考文献 |
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| 相关活性 小分子 |
磺丁醚-beta-环糊精 | 环孢菌素 | 2,7-二氯二氢代荧光黄二醋酸 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | 4′,4”-双-2-咪唑啉-2-基对苯二丙烯酰苯胺二盐酸盐 | 乙莫克舍 | TD139 | Mitoquinone甲磺酸盐 | GSK2795039 | 5,5’,6,6’-四氯-1,1’,3,3’-四乙基苯并咪唑羰花青碘化物 | 胞内钙荧光探针 BAPTA-AM | AP20187 | GKT137831 | D-虫荧光素游离酸 | 野百合碱 |
| 密度 | 1.3±0.1 g/cm3 |
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| 沸点 | 497.8±45.0 °C at 760 mmHg |
| 熔点 | 264?C |
| 分子式 | C20H27NO3 |
| 分子量 | 329.433 |
| 闪点 | 254.8±28.7 °C |
| 精确质量 | 329.199097 |
| PSA | 76.78000 |
| LogP | 3.61 |
| 外观性状 | 黄褐色晶体 |
| 蒸汽压 | 0.0±2.9 mmHg at 25°C |
| 折射率 | 1.610 |
| 储存条件 | -20°C Freezer |
| 水溶解性 | 水溶性：不溶；微溶：二甲基甲酰胺；极微溶：甲醇,乙醇；不溶：二乙醚,氯仿 |
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曲洛司坦毒性英文版
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| 符号 |
GHS07, GHS08 |
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| 信号词 |
Warning |
| 危害声明 |
H315-H319-H361 |
| 警示性声明 |
P281-P305 + P351 + P338 |
| 危害码 (欧洲) |
Xi |
| 风险声明 (欧洲) |
36/37/38-62 |
| 安全声明 (欧洲) |
26-36/37 |
| 危险品运输编码 | NONH for all modes of transport |
| 海关编码 | 2937290090 |
| 海关编码 | 2937290090 |
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Disturbances in production of progesterone and their implications in plant studies. Steroids 96 , 153-63, (2015)
Progesterone is a mammalian hormone that has also been discovered in plants but its physiological function in plants is not explained. Experiments using inhibitors of progesterone synthesis and bindin…
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Guanosine triphosphate can directly regulate cortisol production by activating Ca(2+)-messenger systems in bovine adrenal fasciculata cells. Endocr. J. 63 , 77-85, (2016)
Adenosine triphosphate (ATP) is known to stimulate cortisol production in vitro, however, the effect of guanosine triphosphate (GTP) on cortisol production is not known. We studied the effect of GTP o…
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Trilostane dose versus body weight in the treatment of naturally occurring pituitary-dependent hyperadrenocorticism in dogs. J. Vet. Intern. Med. 26(4) , 1078-80, (2012)
Trilostane is commonly used in the treatment of dogs with naturally occurring pituitary-dependent hyperadrenocorticism (PDH). Dose recommendations have varied from the manufacturer and the literature….
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MODRASTANE |
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(4a,5a,17b)-4,5-Epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile |
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2a-Cyano-4a,5a-epoxyandrostan-17b-ol-3-one |
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Desopan |
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Trilostane |
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MFCD00199295 |
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Modrenal |
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(4α,5α,17β)-3,17-Dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile |
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Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4α,5α,17β)- |
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Modrefen |
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Vetoryl |
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EINECS 237-133-0 |
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4α,5-Epoxy-3,17β-dihydroxy-5α-androst-2-ene-2-carbonitrile |
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Trilostane(Win 24540; Modrastane) |
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