购物 0

This product was successfully added to cart!

View Shopping Cart

Return to Shopping Proceed to Checkout
替宁酸

替宁酸

USD$0.00

品牌商品推荐

更多 >>

  • 苯偶姻异丁基醚

  • 2-吗啉苯硼酸

  • D-二苯甲酰酒石酸

  • 3-氯-5-三氟甲基苯硼酸

  • 1,4-二溴-2,5-二氟苯

  • 去氢紫堇碱

商品详情

客户评价



?替宁酸名称


















中文名

替宁酸
英文名

tienilic acid
中文别名


2,3-二氯-4-(2-噻吩甲酰基)苯氧基乙酸




|



噻吩利尿酸




|



2-(2,3-二氯-4-(噻吩-2-羰基)苯氧基)乙酸



英文别名
更多





?替宁酸生物活性








































描述
铁粉酸是一种尿酸利尿剂。噻吩酸具有一定的肝毒性[1][3]。
相关类别



体内研究

Tienilic acid（大鼠和小鼠为100 mg/lg，猪和狗为5 mg/kg；PO和IV；单次剂量）仅存在于血浆中，通过胆汁和尿液禁食消除，在不同物种中表现出微小差异【2】。替尼酸（0-480 mg/kg；PO；持续28天）可降低血压、血清、尿酸血红蛋白，并增加S-GPT；诱导小群肝细胞的单细胞坏死[3]。动物模型：大鼠、小鼠、猪和狗【2】剂量：大鼠和小鼠100 mg/lg，猪和狗5 mg/kg给药：PO和IV；单次给药结果：仅在血液水平与血浆蛋白有重要结合的血浆中发现；药理作用数小时；在给药后的前48小时内，通过胆道，尤其是尿路禁食，几乎完全消除；在不同物种中测量的参数只有很小的差异。动物模型：雌性和雄性Sprague-Dawley大鼠【3】剂量：0、30、120和480 mg/kg给药：PO；28天结果：30 mg/kg时血压和血尿酸降低；在120和480 mg/kg时，血红蛋白略有下降，S-GPT升高；显著增加雄性大鼠的肝脏重量和血清镁浓度，而雌性大鼠的肝脏重量仅略有增加；此外，诱导小群肝细胞单细胞坏死。
溶解度

In Vitro:

氘代丙酮 : 250 mg/mL (754.90 mM; Need ultrasonic)

DMSO : 100 mg/mL (301.96 mM; Need ultrasonic)
储备液

1 mM 3.0196 mL 15.0980 mL 30.1960 mL
5 mM 0.6039 mL 3.0196 mL 6.0392 mL
10 mM 0.3020 mL 1.5098 mL 3.0196 mL


运输

室温
参考文献

[1]. Lemieux G, et al, Baverel G. Metabolic effects in man of tienilic acid, a new diuretic with uricosuric properties. Nephron. 1978;20(1):54-64.

[2]. Levron, J.C., et al. Pharmacokinetic study of 2,3-dichloro 4- (2-thienyl keto14C) phenoxyacetic acid (tienilic acid) in animals. European Journal of Drug Metabolism and Pharmacokinetics 2, 107–120 (1977).

[3]. Oker-Blom C, et al. Toxicological studies on tienilic acid in rats. Toxicol Lett. 1980;6(2):93-99.






?替宁酸物理化学性质





































密度 1.5±0.1 g/cm3
沸点 534.6±50.0 °C at 760 mmHg
熔点 148-149?C
分子式 C13H8Cl2O4S
分子量 331.17
闪点 277.1±30.1 °C
精确质量 329.952026
PSA 91.84000
LogP 3.07
蒸汽压 0.0±1.5 mmHg at 25°C
折射率 1.632





?替宁酸毒性和生态




替宁酸毒性英文版





?替宁酸安全信息




















危险品运输编码 NONH for all modes of transport
RTECS号 AG9300000
海关编码 2934999090






?替宁酸上下游产品











替宁酸上游产品? 0

替宁酸下游产品? 1










?替宁酸海关















海关编码 2934999090
中文概述 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%








?替宁酸文献28

更多文献














Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity.

Expert Opin. Drug Metab. Toxicol. 10(10) , 1313-24, (2014)

Drug resistance by Plasmodium falciparum remains a challenge in malaria chemotherapy. This paper will focus on physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hy...



Coupling Laser Diode Thermal Desorption with Acoustic Sample Deposition to Improve Throughput of Mass Spectrometry-Based Screening.

J. Biomol. Screen. 21 , 165-75, (2016)

The move toward label-free screening in drug discovery has increased the demand for mass spectrometry (MS)-based analysis. Here we investigated the approach of coupling acoustic sample deposition (ASD...



Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.

Chem. Res. Toxicol. 21(9) , 1814-22, (2008)

In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a resulting toxicological response. On the basis of...







?替宁酸英文别名














































































Tienilic acid


(2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy)acetic acid


Tienilico acido


(2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid


Acidum tienilicum


TienilicAcid


Selacryn


acetic acid, [2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]-


Diflurex


Ticrynafen Tienylic acid [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]-acetic acid


[2,3-dichloro-4-(2-thenoyl)phenoxy]acetic acid


Acido tienilico


Acide tienilique


2,3-dichloro-4-(thien-2-ylcarbonyl)-phenoxyacetic acid


[2,3-dichloro-4-(thiophene-2-carbonyl)-phenoxy]-acetic acid


[2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic acid


Acetic acid, 2-[2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]-


Ticrex


{[2,3-dichloro-4-(2-thienylcarbonyl)phenyl]oxy}acetic acid


Ticrynafen


2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid


Thienylic acid


[2,3-dichloro-4-(thiophen-2-ylcarbonyl)phenoxy]acetic acid








Write a review here:

  • 1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)
    Loading ... Loading ...


    • 7 + = fourteen

    Tags:

    • 海量货源

      1000+化工产品，覆盖300+小类

    • 精品服务

      我们以卓越的服务 已经有超过100家合作伙伴

    • 使命

      科技成就美好出行

    • 核心价值观

      成就客户、价值为纲、开放诚信 以奋斗者为本

    [contact-form-7 id="1574" title="Contact Us"]