枸橼酸托瑞米芬

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中文名	枸橼酸托瑞米芬
英文名	Toremifene Citrate
中文别名	2(4-(4-氯-1,2-二苯基-1-丁烯基)苯氧基-N,N-二甲基乙胺枸橼酸盐 \| 柠檬酸托瑞米芬 \| 2[4-(4-氯-1,2-二苯基-1-丁烯基)苯氧基-N,N-二甲基乙胺枸橼酸盐
英文别名	更多

描述

Toremifene(NK 622; FC 1157a)柠檬酸盐是第二代选择性雌激素受体调节剂，对雌激素受体的IC50为1μM。

相关类别

信号通路 >>

其他 >>

雌激素受体/ERR

研究领域 >>

癌症

溶解度

体外：

在DMSO中10mM

储备液

1 mM	1.6720 mL	8.3601 mL	16.7202 mL
5 mM	0.3344 mL	1.6720 mL	3.3440 mL
10 mM	0.1672 mL	0.8360 mL	1.6720 mL

存储

粉末	-20℃下	3年
	4℃下	2年
在溶剂中	-80℃下	6个月
	-20℃下	1个月

运输

室温;可能会有所不同

SMILES

ClCC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)C3=CC=CC=C3.O=C(CC(C(O)=O)(O)CC(O)=O)O

参考文献

[1]. Matthew R Smith, Selective Estrogen Receptor Modulators to Prevent Treatment-Related Osteoporosis.Rev Urol. 2005; 7(Suppl 3): S30-S35.

[2]. Gauri J Sabnis, Luciana Macedo, Olga Goloubeva, Toremifene – Atamestane; Alone or In Combination: Predictions from the Preclinical Intratumoral Aromatase Model. J Steroid Biochem Mol Biol. 2008 January; 108(1-2): 1-7.

[3]. Taneja SS, Morton R, Barnette G, Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral toremifene. J Clin Oncol. 2013 Feb 10;31(5):523-9.

相关活性
小分子

密度	1.045g/cm3
沸点	535.1?C at 760 mmHg
熔点	158-164?C
分子式	C₃₂H₃₆ClNO₈
分子量	598.083
闪点	277.4?C
精确质量	597.212952
PSA	144.60000
LogP	4.96650
外观性状	白色或近乎于白色粉末
折射率	1.416-1.418
储存条件	-20°C Freezer
水溶解性	DMSO: >10mg/mL

枸橼酸托瑞米芬毒性英文版

符号	GHS05, GHS07, GHS09
信号词	Danger
危害声明	H302-H318-H410
警示性声明	P280-P301 + P312 + P330-P305 + P351 + P338 + P310
危害码 (欧洲)	Xi: Irritant;
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	26-37/39
危险品运输编码	UN 3077 9 / PGIII
RTECS号	KH2156700
海关编码	2942000000

海关编码	2942000000

Use of SERMs for treatment in postmenopausal women

J. Steroid Biochem. Mol. Biol. 142 , 142-54, (2014)

? FDA approved selective estrogen receptor modulators (SERMs) prevent and treat breast cancer, osteoporosis and dyspareunia. ? SERMs have varying agonist and antagonist activities at the level of the …

Novel off-target effect of tamoxifen–inhibition of acid ceramidase activity in cancer cells.

Biochim. Biophys. Acta 1831(12) , 1657-64, (2013)

Acid ceramidase (AC), EC 3.5.1.23, a lysosomal enzyme, catalyzes the hydrolysis of ceramide to constituent sphingoid base, sphingosine, and fatty acid. Because AC regulates the levels of pro-apoptotic…

Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral toremifene.

J. Clin. Oncol. 31(5) , 523-9, (2013)

Prostate cancer (PCa) prevention remains an appealing strategy for the reduction of overtreatment and secondary adverse effects. We evaluated the efficacy of toremifene citrate 20 mg in PCa prevention…

2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine,2-hydroxypropane-1,2,3-tricarboxylic acid

2-{4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxy-1,2,3-propanetricarboxylate (salt)

2-{4-[(1Z)-4-Chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (1:1)

2-{4-[(1Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Toremifene Citrate

2-{4-[(1Z)-4-chloro-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (salt)

ethanamine, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)

2-Hydroxypropan-1,2,3-tricarbons?ure–2-{4-[(1Z)-4-chlor-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamin(1:1)

acide 2-hydroxypropane-1,2,3-tricarboxylique – 2-{4-[(1Z)-4-chloro-1,2-diphénylbut-1-én-1-yl]phénoxy}-N,N-diméthyléthanamine (1:1)

Ethanamine, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)

Toremifene (Citrate)

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枸橼酸托瑞米芬

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