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樱花亭

樱花亭

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?樱花亭名称


















中文名

樱花亭
英文名

Sakuranetin
中文别名


樱花素




|



4,5-二羥-7-甲氧黃烷酮



英文别名
更多





?樱花亭生物活性










































描述
Sakuranetin 是一种大米黄酮类植物抗毒素,具有很强的抗真菌活性。Sakuranetin 具有抗炎和抗氧化作用,能够改善 LPS 诱导的急性肺损伤。
相关类别




溶解度

体外:

DMSO: ≥125mg / mL436.64 mM

* “≥”表示可溶,但饱和度未知。

体内:

1.逐个添加每种溶剂:10%DMSO 90%玉米油

溶解度:≥2.08mg / mL(7.27 mM);明确解决方案

2.逐个加入各溶剂:10%DMSO 40%PEG300 5%Tween-80 45%盐水

溶解度:≥2.08mg / mL(7.27 mM);明确解决方案

3.逐个添加每种溶剂:10%DMSO 90%(20%SBE-β-CD在盐水中)

溶解度:≥2.08mg / mL(7.27 mM);明确解决方案


储备液

1 mM 3.4931 mL 17.4654 mL 34.9308 mL
5 mM 0.6986 mL 3.4931 mL 6.9862 mL
10 mM 0.3493 mL 1.7465 mL 3.4931 mL


存储

粉末 -20°C 3年
? 4°C 2年
在溶剂中 -80°C 6月
? -20°C 1月


运输

室温
SMILES

O=C1C2=C(O)C=C(OC)C=C2O[C@H](C3=CC=C(O)C=C3)C1
参考文献

[1]. Hasegawa M, et al. Analysis on blast fungus-responsive characters of a flavonoid phytoalexin sakuranetin; accumulation in infected rice leaves, antifungal activity and detoxification by fungus. Molecules. 2014 Aug 4;19(8):11404-18.

[2]. Bittencourt-Mernak MI, et al. Prophylactic and therapeutic treatment with the flavonone sakuranetin ameliorates LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L217-L230.







?樱花亭物理化学性质





































密度 1.4±0.1 g/cm3
沸点 555.9±50.0 °C at 760 mmHg
熔点 153-154?C
分子式 C16H14O5
分子量 286.28
闪点 212.4±23.6 °C
精确质量 286.084137
PSA 75.99000
LogP 3.37
蒸汽压 0.0±1.6 mmHg at 25°C
折射率 1.638






?樱花亭安全信息


























符号

GHS07


GHS07
信号词
Warning
危害声明
H302
危害码 (欧洲)
Xn
风险声明 (欧洲)
22
危险品运输编码 NONH for all modes of transport














?樱花亭文献24

更多文献














A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.

Fitoterapia 98 , 11-21, (2014)

The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivativ…





In vitro antileishmanial and antitrypanosomal activities of flavanones from Baccharis retusa DC. (Asteraceae).

Exp. Parasitol. 130(2) , 141-5, (2012)

Leishmaniasis and Chagas’ are parasitic protozoan diseases that affect the poorest population in the world, causing a high mortality and morbidity. As a result of highly toxic and long-term treatments…





Isoprenylated flavonoid and adipogenesis-promoting constituents of Dodonaea viscosa.

J. Nat. Prod. 75(4) , 699-706, (2012)

Ten new isoprenylated flavonol derivatives, dodoviscins A-J (1-10), and seven known compounds (11-17) were isolated from the aerial parts of Dodonaea viscosa. Compounds 1, 2, 4, 5, 7-9, 5,7,4′-trihydr…









?樱花亭英文别名






















































5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydrochromen-4-one


4′,5-Dihydroxy-7-methoxyflavanone


(S)-(-)-4′,5-dihydroxy-7-methoxyflavanone


4′,5-DIHYDROXY-7-METHOXYFLAVONE


4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-, (2S)-


Naringenin 7-O-methyl ether


5,4′-dihydroxy-7-methoxyflavanone


(2S)-sakuranetin


7-O-Methylnaringenin


naringenin 7-methylether


(S)-(-)-4′,5-Dihydroxy-7-methoxy-flavanone


(2S)-5-Hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydro-4H-chromen-4-one


Sakuranetin


Naringenin 7-methyl ether


EINECS 220-980-5








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