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氧阿苯达唑

氧阿苯达唑

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?氧阿苯达唑名称


















中文名

氧阿苯达唑
英文名

albendazole S-oxide
中文别名


阿苯达唑亚砜(丙硫咪唑亚砜)




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阿苯达唑杂质B




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N-(6-丙基亚硫酰-1H-苯并咪唑-2-基)氨基甲酸甲酯




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阿苯达唑亚砜



英文别名
更多





?氧阿苯达唑生物活性






































描述
Albendazole sulfoxide (Ricobendazole) 是Albendazole 的主要代谢物,具有抗寄生虫活性 (e.g. Echinococcus multilocularis)。
相关类别


溶解度

In Vitro:

DMSO : 25 mg/mL (88.86 mM; Need ultrasonic)

In Vivo:

1.

请依序添加每种溶剂:?10% DMSO ?? 40% PEG300 ?? 5% Tween-80 ?? 45% saline

Solubility: ≥ 2.08 mg/mL (7.39 mM); Clear solution

2.

请依序添加每种溶剂:?10% DMSO ?? 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (7.39 mM); Clear solution

3.

请依序添加每种溶剂:?10% DMSO ?? 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.39 mM); Clear solution


储备液

1 mM 3.5545 mL 17.7727 mL 35.5454 mL
5 mM 0.7109 mL 3.5545 mL 7.1091 mL
10 mM 0.3555 mL 1.7773 mL 3.5545 mL


SMILES

O=C(OC)NC1=NC2=CC=C(S(CCC)=O)C=C2N1
参考文献

[1]. Gokhan Adas,, et al. Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study).







?氧阿苯达唑物理化学性质









































密度 1.4±0.1 g/cm3
沸点 357.3?C at 760 mmHg
熔点 154-156?C
分子式 C12H15N3O3S
分子量 281.331
闪点 169.9?C
精确质量 281.083405
PSA 103.29000
LogP 0.91
外观性状 白色至灰白色粉末
折射率 1.659
储存条件 -20°C Freezer






?氧阿苯达唑安全信息






























符号

GHS07


GHS07
信号词
Warning
危害声明
H302
个人防护装备
dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)
Xn
风险声明 (欧洲)
22
危险品运输编码 NONH for all modes of transport
RTECS号 FD1080000






?氧阿苯达唑上下游产品











氧阿苯达唑上游产品? 3

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?氧阿苯达唑文献32

更多文献














Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism.

J. Anal. Toxicol. 39 , 374-86, (2015)

Opioid-related mortality rates have escalated. Drug interactions may increase blood concentrations of the opioid. We therefore used human liver microsomes (HLMs) and cDNA-expressed human cytochrome P4…





Validation of a streamlined multiclass, multiresidue method for determination of veterinary drug residues in bovine muscle by liquid chromatography-tandem mass spectrometry.

Anal. Bioanal. Chem 407 , 4423-35, (2015)

Multiclass, multiresidue methods are becoming increasingly popular in regulatory monitoring programs due to their increased analytical scope and laboratory efficiency. In this work, we report the deve…





The transport of albendazole and albendazole sulphoxide in the lancet fluke (Dicrocoelium dendriticum).

Vet. Parasitol. 176(1) , 27-33, (2011)

Albendazole (ABZ) is one of the most important benzimidazole compounds possessing high activity against the lancet fluke, Dicrocoelium dendriticum. ABZ sulphoxide (ABZ.SO) is the main molecule present…









?氧阿苯达唑英文别名







































Rycobendazole


Carbamic acid, N-[5-(propylsulfinyl)-1H-benzimidazol-2-yl]-, methyl ester


carbamic acid, N-[6-(propylsulfinyl)-1H-benzimidazol-2-yl]-, methyl ester


MFCD00797922


Albendazole Sulfoxide


Albendazole S-oxide


Ricobendazole


Albendazole sulphoxide


Methyl [5-(propylsulfinyl)-1H-benzimidazol-2-yl]carbamate


Albendazole oxide








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