水飞蓟亭

中文名	水飞蓟亭
英文名	silychristin
中文别名	水飞蓟丁 \| 水飞蓟汀
英文别名	更多

描述	Silychristin 是水飞蓟果实中富含的黄酮类化合物，具有抗氧化作用。Silychristin 是甲状腺激素转运体 MCT8 的有效抑制剂，能强烈抑制 T3 的摄取，其 IC50 为 110 nM。
相关类别	研究领域 >> 内分泌信号通路 >> 其他 >> 其他
SMILES	O=C1[C@H](O)[C@@H](C2=CC(O)=C(O[C@@H](C3=CC=C(O)C(OC)=C3)[C@@H]4CO)C4=C2)OC5=CC(O)=CC(O)=C15
参考文献	[1]. Biedermann D, et al. Silychristin: Skeletal Alterations and Biological Activities. J Nat Prod. 2016 Dec 23;79(12):3086-3092. [2]. Johannes J, et al. Silychristin, a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8. Endocrinology. 2016 Apr;157(4):1694-701.

密度	1.6±0.1 g/cm3
沸点	782.0±60.0 °C at 760 mmHg
分子式	C₂₅H₂₂O₁₀
分子量	482.436
闪点	270.5±26.4 °C
精确质量	482.121307
PSA	166.14000
LogP	2.20
蒸汽压	0.0±2.8 mmHg at 25°C
折射率	1.716
储存条件	2-8°C

符号	GHS07
信号词	Warning
危害声明	H302
危害码 (欧洲)	Xn
风险声明 (欧洲)	22
安全声明 (欧洲)	22-45
危险品运输编码	NONH for all modes of transport

水飞蓟亭上游产品? 3
CAS号1835-11-6 4-苄氧基-3-甲氧基苯乙酮 CAS号124662-51-7 1-(4-benzyloxy-… CAS号16414-34-9 6-溴-2_3-二羟基苯甲醛
水飞蓟亭下游产品? 0

水飞蓟亭上游产品? 3

CAS号1835-11-6
4-苄氧基-3-甲氧基苯乙酮

CAS号124662-51-7
1-(4-benzyloxy-…

CAS号16414-34-9
6-溴-2_3-二羟基苯甲醛

水飞蓟亭下游产品? 0

Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes.

Pharmacol. Res. 25(2) , 147-54, (1992)

The effect of several flavanolignans (silicristin, silidianin, silybin and isosilybin) present in silymarin, the extract of Silybum marianum fruits, was tested on lipid peroxidation in rat liver micro…

Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.

J. Chromatogr. A. 1116(1-2) , 57-68, (2006)

A selective and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method has been developed for the characterization of silymarin in commercially available milk thistle extract. In t…

Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.

Int. J. Cancer 123(1) , 41-50, (2008)

Prostate cancer (PCa) is the leading cause of cancer-related deaths in men; urgent measures are warranted to lower this deadly malignancy. Silymarin is a known cancer chemopreventive agent, but the re…

Silicristin

EINECS 251-720-9

Silicristinum

(2R,3R)-3,5,7-trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]-2,3-dihydrochromen-4-one

Silicristinum [INN-Latin]

Silicristina

(2R,3R)-3,5,7-Trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]-2,3-dihydro-4H-chromen-4-one

Silicristina [INN-Spanish]

4H-1-Benzopyran-4-one, 2-[(2R,3S)-2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-

Silychristin

Silymarin II

Silicristine [INN-French]

(2R,3R)-3,5,7-trihydroxy-2-[(2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-2,3-dihydrobenzofuran-5-yl]chroman-4-one

Silicristine

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