水飞蓟宁

中文名	水飞蓟宁
英文名	silydianin
中文别名	异水飞蓟素
英文别名	更多

描述	Silydianin 是水飞蓟的活性成分，具有抗胶原酶和抗弹性酶活性。Silydianin 是一种天然的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，其 IC50 值为 17.38 μM。Silydianin 对氧化产物的体外产生和释放具有抑制作用。
相关类别	研究领域 >> 癌症信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶
SMILES	O=C1[C@]2([H])C=C([C@@H]3[C@@H](O)C(C4=C(O)C=C(O)C=C4O3)=O)[C@@]5([H])[C@]([C@H]2C6=CC=C(O)C(OC)=C6)([H])CO[C@]51O
参考文献	[1]. Vostálová J, et al. Skin Protective Activity of Silymarin and its Flavonolignans. Molecules. 2019 Mar 14;24(6). [2]. Qin N, et al. Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1283-1291. [3]. Zielińska-Przyjemska M, et al. An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. Phytother Res. 2006 Feb;20(2):115-9.

密度	1.7±0.1 g/cm3
沸点	819.0±65.0 °C at 760 mmHg
分子式	C₂₅H₂₂O₁₀
分子量	482.436
闪点	285.0±27.8 °C
精确质量	482.121307
PSA	162.98000
LogP	1.84
蒸汽压	0.0±3.1 mmHg at 25°C
折射率	1.747
储存条件	2-8°C

符号	GHS07
信号词	Warning
危害声明	H302
警示性声明	P301 + P312 + P330
危害码 (欧洲)	Xn
风险声明 (欧洲)	22
安全声明 (欧洲)	22-45
危险品运输编码	NONH for all modes of transport

Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes.

Pharmacol. Res. 25(2) , 147-54, (1992)

The effect of several flavanolignans (silicristin, silidianin, silybin and isosilybin) present in silymarin, the extract of Silybum marianum fruits, was tested on lipid peroxidation in rat liver micro…

[Silymarin in the treatment of chronic liver diseases: past and future].

Orv. Hetil. 149(51) , 2413-8, (2008)

In the treatment of chronic liver diseases adequate therapy can be chosen only in the knowledge of pathogenetic processes. In the liver diseases caused by oxidative stress (alcoholic and non-alcoholic…

Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.

J. Chromatogr. A. 1116(1-2) , 57-68, (2006)

A selective and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method has been developed for the characterization of silymarin in commercially available milk thistle extract. In t…

Silidianin

Silydianin

(1R,3R,6R,7R,10R)-3-Hydroxy-10-(4-hydroxy-3-methoxyphenyl)-8-[(2R,3R)-3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]-4-oxatricyclo[4.3.1.0]dec-8-en-2-one

Silydianin (20 mg)

Silychristin

3,6-Methanobenzofuran-7(6H)-one, 4-[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-, (3R,3aR,6R,7aR,8R)-

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