牛蒡子苷

中文名	牛蒡子苷
英文名	Arctiin
中文别名	牛蒡苷
英文别名	更多

描述

Arctiin(NSC 315527)是植物木酚素，可从牛蒡种子中提取，具有抗癌活性。

相关类别

信号通路 >>

其他 >>

其他

天然产物 >>

苯丙酸类

研究领域 >>

癌症

溶解度

体外：

DMSO：≥5.4mg / mL（10.10 mM）

* “≥”表示可溶，但饱和度未知。

储备液

1 mM	1.8707 mL	9.3537 mL	18.7073 mL
5 mM	0.3741 mL	1.8707 mL	3.7415 mL
10 mM	0.1871 mL	0.9354 mL	1.8707 mL

存储

粉末	-20℃下	3年
	4℃下	2年
在溶剂中	-80℃下	6个月
	-20℃下	1个月

运输

室温;可能会有所不同

SMILES

O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=C(OC)C=C(C[C@H]3C(OC[C@@H]3CC4=CC(OC)=C(OC)C=C4)=O)C=C2)[C@@H]1O

参考文献

[1]. Huang DM, et al. Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells. Prostate. 2004 May 15;59(3):260-7.

[2]. Knipping K, et al. In vitro and in vivo anti-allergic effects of Arctium lappa L. Exp Biol Med (Maywood). 2008 Nov;233(11):1469-77.

[3]. Zeng Y, et al. Lack of significant modifying effect of arctiin on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Lett. 2005 May 26;222(2):145-51.

[4]. Wu JG, et al. Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats. Phytomedicine. 2009 Nov;16(11):1033-41.

[5]. Ma ST, et al. Effect of arctiin on glomerular filtration barrier damage in STZ-induced diabetic nephropathy rats. Phytother Res. 2013 Oct;27(10):1474-80.

[6]. Matsuzaki Y, et al. Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep. 2008 Mar;19(3):721-7.

相关活性
小分子

密度	1.4±0.1 g/cm3
沸点	756.4±60.0 °C at 760 mmHg
熔点	109 °C
分子式	C₂₇H₃₄O₁₁
分子量	534.552
闪点	250.1±26.4 °C
精确质量	534.210083
PSA	153.37000
LogP	0.23
外观性状	白色至灰白色固体
蒸汽压	0.0±2.7 mmHg at 25°C
折射率	1.601
储存条件	?20°C

危险品运输编码	NONH for all modes of transport

Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS.

Planta Med. 78(8) , 800-6, (2012)

The pharmacokinetic profile of arctiin, the major active lignan in fruits of Arctium lappa L., was investigated. Its main meta”bolite arctigenin was identified by an LC-MS method, and an HPLC-UV techn…

Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC.

Fitoterapia 86 , 6-12, (2013)

Arctiin, an important lignan compound in Fructus Arctii, has been reported to possess various kinds of bioactivities. Previous studies on the pharmacokinetic of arctiin after oral administration showe…

Effects of arctiin on streptozotocin-induced diabetic retinopathy in Sprague-Dawley rats.

Planta Med. 78(12) , 1317-23, (2012)

Diabetic retinopathy is one of the most common and severe complications of diabetes mellitus. Arctiin, a bioactive compound isolated from the dry seeds of Arctium lappa L., has been reported to have a…

MFCD00870630

Arctiin (8CI)

4-{[(3R,4R)-4-(3,4-Dimethoxybenzyl)-2-oxotetrahydro-3-furanyl]methyl}-2-methoxyphenyl β-D-glucopyranoside

Arctigenin-4-glucoside

Arctin

Arctlin

2(3H)-Furanone, 4-[(3,4-dimethoxyphenyl)methyl]-3-[[4-(b-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-

Arctiin

4-{[(3R,4R)-4-(3,4-Dimethoxybenzyl)-2-oxotetrahydrofuran-3-yl]methyl}-2-methoxyphenyl β-D-glucopyranoside

2(3H)-Furanone, 4-[(3,4-dimethoxyphenyl)methyl]-3-[[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-, (3R,4R)-

Great Burdock Root Extract

NSC 315527

Acrctiin

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牛蒡子苷名称

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