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球松素

球松素

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?球松素名称


















中文名

球松素
英文名

pinostrobin
中文别名


5-羟基-7-甲氧基-2-苯基色满-4-酮




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乔松酮




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5-羟基-7-甲氧基黄烷酮



英文别名
更多





?球松素生物活性




































描述
Pinostrobin 是一种黄酮类化合物,可在许多植物中发现,并具有抗氧化,抗炎,抗癌和神经保护的特性。 Pinostrobin 是一种有效的 PCSK9 抑制剂,可抑制 PCSK9 的催化活性。Pinostrobin 是一种有前景的胆固醇调节和脂质管理剂。
相关类别



靶点

IC50: PCSK9[1]


SMILES

O=C1C[C@@H](C2=CC=CC=C2)OC3=CC(OC)=CC(O)=C13
参考文献

[1]. Gao WY, et al. Pinostrobin Inhibits Proprotein Convertase Subtilisin/Kexin-type 9 (PCSK9) Gene Expression through the Modulation of FoxO3a Protein in HepG2 Cells.J Agric Food Chem. 2018 Jun 20;66(24):6083-6093.







?球松素物理化学性质





































密度 1.3±0.1 g/cm3
沸点 494.9±45.0 °C at 760 mmHg
熔点 100?C
分子式 C16H14O4
分子量 270.280
闪点 188.8±22.2 °C
精确质量 270.089203
PSA 55.76000
LogP 4.11
蒸汽压 0.0±1.3 mmHg at 25°C
折射率 1.612






?球松素安全信息




































符号

GHS07


GHS07
信号词
Warning
危害声明
H315-H319-H335
警示性声明
P261-P305 + P351 + P338
个人防护装备
dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)
Xi: Irritant;
风险声明 (欧洲)
R36/37/38
安全声明 (欧洲)
S26-S36
危险品运输编码 NONH for all modes of transport
WGK德国 3
海关编码 2932999099











?球松素海关















海关编码 2932999099
中文概述 2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%








?球松素文献11

更多文献














Phloroglucinols from anti-microbial deposit-resins of Australian stingless bees (Tetragonula carbonaria).

Phytother Res. 29(1) , 48-58, (2015)

Stingless bees accumulate deposits of plant resins that are mixed with beeswax to produce propolis. Previous studies have reported anti-microbial constituents of stingless bee (Tetragonula carbonaria)…





Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells.

J. Nat. Prod. 73 , 623-7, (2010)

Three new flavonoids, (2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate (1), (7”R)-8-[1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl]chrysin (2), and (7”R)-8-[1-(4′-hydroxy-3′-methoxyphen…





Cytotoxic flavonoids from the leaves of Cryptocarya chinensis.

J. Nat. Prod. 73 , 1470-5, (2010)

Bioassay-guided fractionation led to the isolation of six new tetrahydroflavanones, cryptochinones A-F (1-6), from the neutral CHCl(3) fraction of Cryptocarya chinensis leaves, together with 14 known …









?球松素英文别名













































Dihydrotectochrysin


4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-7-methoxy-2-phenyl-, (S)-


Pinostrobin


2-Phenyl-5-hydroxy-7-methoxy-2,3-dihydro-4H-1-benzopyran-4-one


(S)-5-Hydroxy-7-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one


Pistrobin


Pinocembrin-7-methyl ether


5-Hydroxy-7-methoxy-2-phenyl-chroman-4-one


(2S)-5-Hydroxy-7-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one


2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one


Pinostobin


4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-7-methoxy-2-phenyl-, (2S)-








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