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瑞舒伐他汀中间体Z-8.1

瑞舒伐他汀中间体Z-8.1

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?瑞舒伐他汀中间体Z-8.1名称


















中文名

N-[5-(联苯-膦酰基甲基)-4-(4-氟-苯基)-6-异丙基-嘧啶-2-基]-N-甲基-甲烷磺胺
英文名

N-[5-(diphenylphosphorylmethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide
中文别名


罗苏伐他汀 中间体ZD-9




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4-(4-氟苯基)-5-三苯基磷溴-6-异丙基-2-[(N-甲基-N-甲磺酰胺基)]-嘧啶




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N-[4-(4-氟苯基)-5-(二苯基氧膦基)甲基-6-异丙基-2-嘧啶基]-N-甲基甲磺酰胺基




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N-[5-(二苯基膦酰甲基)-4-(4-氟苯基)-6-异丙基嘧啶-2-基]-N-甲基甲磺酰胺




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N-[5-(二苯基膦酰甲基)-4-(4-氟苯基)-6-异丙基嘧啶-2-基]-N-甲基甲磺酰胺




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瑞舒伐他汀钙中间体



英文别名
更多








?瑞舒伐他汀中间体Z-8.1物理化学性质



































密度 1.3±0.1 g/cm3
沸点 679.1±65.0 °C at 760 mmHg
分子式 C28H29FN3O3PS
分子量 537.585
闪点 364.5±34.3 °C
精确质量 537.165100
PSA 98.42000
LogP 3.21
蒸汽压 0.0±2.1 mmHg at 25°C
折射率 1.625





?瑞舒伐他汀中间体Z-8.1合成线路

































~71%







瑞舒伐他汀中间体Z-8.1结构式

瑞舒伐他汀中间体Z-8.1

289042-10-0






文献:WO2004/103977 A2, ; Page 24-25 ;









~%







瑞舒伐他汀中间体Z-8.1结构式

瑞舒伐他汀中间体Z-8.1

289042-10-0






文献:US2004/49036 A1, ; Page 2; 3 ;









~24%







瑞舒伐他汀中间体Z-8.1结构式

瑞舒伐他汀中间体Z-8.1

289042-10-0






文献:US6160115 A1, ;





~%







瑞舒伐他汀中间体Z-8.1结构式

瑞舒伐他汀中间体Z-8.1

289042-10-0






文献:US6160115 A1, ;





~%







瑞舒伐他汀中间体Z-8.1结构式

瑞舒伐他汀中间体Z-8.1

289042-10-0






文献:WO2012/2741 A2, ; WO 2012/002741 A2





~%







瑞舒伐他汀中间体Z-8.1结构式

瑞舒伐他汀中间体Z-8.1

289042-10-0






文献:WO2012/2741 A2, ; WO 2012/002741 A2




















?瑞舒伐他汀中间体Z-8.1英文别名
















































Methanesulfonamide, N-[5-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-


N-{5-[(Diphenylphosphoryl)methyl]-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl}-N-methylmethanesulfonamide


diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-ylmethyl]phosphine oxide


N-[5-(diphenyl-phosphinoylmethyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide


N-{5-[(diphenylphosphoryl)methyl]-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl}-N-methylmethanesulfonamide


diphenyl [4-(4-fluoropheny)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-ylmethyl] phosphine oxide


N-[5-[(diphenylphosphinoyl)-methyl]-4-(4-fluorophenyl)-6-isopropyl-pyrimidindin-2-yl]-N-methyl-methanesulfonamide


diphenyl[2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-ylmethyl]phosphine oxide


N-{5-[(Diphenylphosphoryl)methyl]-4-(4-fluorphenyl)-6-(propan-2-yl)pyrimidin-2-yl}-N-methylmethansulfonamid


AC-3407


N-{5-[(Diphenylphosphoryl)methyl]-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl}-N-methylmethanesulfonamide


N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide


Methanesulfonamide,N-[5-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl








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