甲磺酸加替沙星

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中文名	甲磺酸加替沙星
英文名	1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,methanesulfonic acid
英文别名	更多

描述

Gatifloxacin甲磺酸盐是第四代氟喹诺酮类抗生素，能抑制细菌的DNA旋转酶和拓扑异构酶IV。

相关类别

信号通路 >>

抗感染 >>

细菌

研究领域 >>

感染

溶解度

体外：

在DMSO中10mM

储备液

1 mM	2.1209 mL	10.6045 mL	21.2089 mL
5 mM	0.4242 mL	2.1209 mL	4.2418 mL
10 mM	0.2121 mL	1.0604 mL	2.1209 mL

存储

请将产品存放在分析证书中的建议条件下。

运输

室温;可能会有所不同

SMILES

CC1NCCN(C2=C(F)C=C3C(N(C4CC4)C=C(C(O)=O)C3=O)=C2OC)C1.O=S(C)(O)=O

参考文献

[1]. Fukuda, H., S. Hori, and K. Hiramatsu, Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. A

[2]. Jensen, H., et al., Comparison of ophthalmic gatifloxacin 0.3% and ciprofloxacin 0.3% in healing of corneal ulcers associated with Pseudomonas aeruginosa-induced ulcerative keratitis in rabbits. J Ocul Pharmacol Ther, 2005. 21(1): p. 36-43.

[3]. Cheung, O., et al., Gatifloxacin-induced hepatotoxicity and acute pancreatitis. Ann Intern Med, 2004. 140(1): p. 73-4.

[4]. Fteha, A., et al., Gatifloxacin induced torsades de pointes. Pacing Clin Electrophysiol, 2004. 27(10): p. 1449-50.

相关活性
小分子

分子式	C₂₀H₂₆FN₃O₇S
分子量	471.500
精确质量	471.147552
PSA	146.55000
LogP	2.95900

1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid methanesulfonate (1:1)

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-, methanesulfonate (1:1)

Gatifloxacin mesylate

1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate (1:1)

Gatifloxacin (mesylate)

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甲磺酸加替沙星

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3-碘苯甲醇

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商品详情

客户评价