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盐酸二氟沙星

盐酸二氟沙星

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?盐酸二氟沙星名称


















中文名

盐酸二氟沙星
英文名

Difloxacin Hydrochloride Salt
中文别名


双氟沙星盐酸盐




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二氟沙星/1-(4-氟苯基)-6-氟-4-氧代-1,4-二氢-7-(4-甲基-1-哌嗪基)-3-喹啉羧酸盐酸盐




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6-氟-1-(4-氟苯基)-7-(4-甲基哌嗪-1-基)-4-氧代喹啉-3-羧酸盐酸盐




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盐酸双氟沙星



英文别名
更多





?盐酸二氟沙星生物活性


































描述
Difloxacin hydrochloride 是一种广谱抗菌药物。Difloxacin hydrochloride 通过干扰 DNA 促旋酶和拓扑异构酶 IV 的活性可抑制细菌 DNA 促旋酶和显示出浓度依赖性的杀菌作用。
相关类别



SMILES

O=C(C1=CN(C2=CC=C(F)C=C2)C3=C(C=C(F)C(N4CCN(C)CC4)=C3)C1=O)O.[H]Cl
参考文献

[1]. Abo El-Ela FI, et al. Pharmacokinetics of difloxacin in healthy and E. coli-infected broiler chickens. Br Poult Sci. 2014;55(6):830-6.







?盐酸二氟沙星物理化学性质









































密度 1.409 g/cm3
沸点 595.5?C at 760 mmHg
熔点 >245?C (dec.)
分子式 C21H20ClF2N3O3
分子量 435.852
闪点 313.9?C
精确质量 435.116119
PSA 65.78000
LogP 3.52380
外观性状 灰白色至淡黄色固体
折射率 1.629
储存条件 0-6°C






?盐酸二氟沙星MSDS








?盐酸二氟沙星安全信息




















个人防护装备
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码 NONH for all modes of transport
RTECS号 VB2008975














?盐酸二氟沙星文献34

更多文献














Determination of fluoroquinolones in chicken feces – a new liquid-liquid extraction method combined with LC-MS/MS.

Environ. Toxicol. Pharmacol. 38(3) , 792-9, (2014)

The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate enviro…





Occurrence and distribution of antibiotics in urban soil in Beijing and Shanghai, China.

Environ. Sci. Pollut. Res. Int. 22 , 11360-71, (2015)

The recycling of reclaimed wastewater for irrigation and road cleaning is an important strategy to minimize water scarcity in megacities. However, little is known regarding the potential accumulation …





Facile synthesis of polyaniline-coated SiO? nanofiber and its application in enrichment of fluoroquinolones from honey samples.

Talanta 140 , 29-35, (2015)

In this study, polyaniline coated SiO2 nanofibers (PANI/SiO2) was prepared by combining electrospinning technique with in-situ polymerization. The proposed strategy for the preparation of PANI/SiO2 ca…









?盐酸二氟沙星英文别名















MFCD03840489


6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,hydrochloride








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