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盐酸去甲乌药碱

盐酸去甲乌药碱

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?盐酸去甲乌药碱名称


















中文名

盐酸去甲乌头碱
英文名

1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydro chloride (1:1)
中文别名


1-(4-羟基苄基)-6,7-二羟基-1,2,3,4-四氢异喹啉盐酸盐




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盐酸去甲乌药碱




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去甲乌药碱盐酸盐




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6,7-二羟基-1-(4-羟基苄基)-1,2,3,4-四氢异喹啉盐酸盐



英文别名
更多





?盐酸去甲乌药碱生物活性




































描述
Higenamine hydrochloride (Norcoclaurine hydrochloride) 是一种 β2-AR 激动剂,是东亚国家治疗心力衰竭的中药乌头的关键成分。Higenamine hydrochloride (Norcoclaurine hydrochloride) 具有抗凋亡作用。
相关类别




靶点

β2-AR[1]


SMILES

OC1=CC2=C(C(CC3=CC=C(O)C=C3)NCC2)C=C1O.[H]Cl
参考文献

[1]. Wu MP, et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 2016 Feb;104:115-23.

[2]. Lee SR, et al. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acidsand energy expenditure in human subjects. Lipids Health Dis. 2013 Oct 21;12:148.







?盐酸去甲乌药碱物理化学性质





























沸点 522.4?C at 760 mmHg
分子式 C16H18ClNO3
分子量 307.772
闪点 209.6?C
精确质量 307.097534
PSA 72.72000
LogP 3.36370
蒸汽压 1.56E-11mmHg at 25°C





?盐酸去甲乌药碱毒性和生态




盐酸去甲乌药碱毒性英文版






?盐酸去甲乌药碱安全信息
















海关编码 2933499090





?盐酸去甲乌药碱合成线路



































~%







盐酸去甲乌药碱结构式

盐酸去甲乌药碱

11041-94-4






文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 – 2029





~%







盐酸去甲乌药碱结构式

盐酸去甲乌药碱

11041-94-4






文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 – 2029





~%







盐酸去甲乌药碱结构式

盐酸去甲乌药碱

11041-94-4






文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 – 2029





~%







盐酸去甲乌药碱结构式

盐酸去甲乌药碱

11041-94-4






文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 – 2029





~%







盐酸去甲乌药碱结构式

盐酸去甲乌药碱

11041-94-4






文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 – 2029





~%







盐酸去甲乌药碱结构式

盐酸去甲乌药碱

11041-94-4






文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 – 2029





~%







盐酸去甲乌药碱结构式

盐酸去甲乌药碱

11041-94-4






文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 – 2029





~%







盐酸去甲乌药碱结构式

盐酸去甲乌药碱

11041-94-4






文献:Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 – 2029















?盐酸去甲乌药碱海关















海关编码 2933499090
中文概述 2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%










?盐酸去甲乌药碱英文别名



























pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-6(7H)-one


1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrochloride (1:1)


6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride


Higenamine HCl


UNII:PQ432PID6E


6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1)








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