盐酸帕洛诺司琼

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中文名	帕洛诺司琼盐酸盐
英文名	palonosetron hydrochloride
中文别名	盐酸帕洛诺司琼
英文别名	更多

描述

Palonosetron盐酸盐是5-HT3拮抗剂，能抑制化疗引起的恶心呕吐（CINV）。

相关类别

信号通路 >>

G 蛋白偶联受体/G 蛋白 >>

5-HT受体

信号通路 >>

神经信号通路 >>

5-HT受体

研究领域 >>

心血管疾病

溶解度

体外：

DMSO：6.8 mg / mL（20.43 mM;需要超声波和加热）

储备液

1 mM	3.0042 mL	15.0209 mL	30.0418 mL
5 mM	0.6008 mL	3.0042 mL	6.0084 mL
10 mM	0.3004 mL	1.5021 mL	3.0042 mL

存储

4°C，避光

运输

室温;可能会有所不同

SMILES

O=C1N(C[C@@]([H])(CCC2)C3=C2C=CC=C13)[C@@H]4CN5CCC4CC5.[H]Cl

参考文献

[1]. Vishnu Murthy M, Srinivas K, Kumar R, Mukkanti K. Development and validation of a stability-indicating LC method for determining palonosetron hydrochloride, its related compounds and degradation products using naphthalethyl stationary phase. J Pharm Bio

[2]. Ajioka H, Morita F, Akizawa Y, Yoshida K, Kitamura R, Takimoto H. Pharmacological, pharmacokinetic, and clinical profile of palonosetron hydrochloride (ALOXI I.V. Injection 0.75 mg), a novel antiemetic 5-HT3-receptor antagonist.Nihon Yakurigaku Zasshi. 2

[3]. Ruhlmann C, Herrstedt J. Palonosetron hydrochloride for the prevention of chemotherapy-induced nausea and vomiting. Expert Rev Anticancer Ther. 2010 Feb;10(2):137-48.

[4]. Trissel LA, Trusley C, Ben M, Kupiec TC. Physical and chemical stability of palonosetron hydrochloride with five opiate agonists during simulated Y-site administration. Am J Health Syst Pharm. 2007 Jun 1;64(11):1209-13.

[5]. Clark, Robin D.; Miller, Aaron B.; Berger, Jacob; Repke, David B.; Weinhardt, Klaus K.; Kowalczyk, Bruce A.; Eglen, Richard M.; Bonhaus, Douglas W.; Lee, Chi Ho; et al.2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformati

相关活性
小分子

沸点	470.4?C at 760 mmHg
熔点	>290?C
分子式	C₁₉H₂₅ClN₂O
分子量	332.868
闪点	209.5?C
精确质量	332.165527
PSA	23.55000
LogP	3.33430
外观性状	白色固体
蒸汽压	5.07E-09mmHg at 25°C
储存条件	Refrigerator

盐酸帕洛诺司琼MSDS英文版

符号	GHS07
信号词	Warning
危害声明	H302
警示性声明	P301 + P312 + P330
危险品运输编码	NONH for all modes of transport
海关编码	2933990090

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1H-Benz[de]isoquinolin-1-one, 2-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-, (3aS)-, hydrochloride (1:1)

Palonosetron Hydrochloride

RS 25259-197

(3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride (1:1)

(3aS)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride

(3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one,hydrochloride

(3aS)-2-((3S)-1-Azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one Monohydrochloride

(3aS)-2,3,3a,4,5,6-Hexahydro-2-[(3S)-3-quinuclidinyl]-1H-benz[de]isoquinolin-1-one Monohydrochloride

MFCD07370072

(3aS)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinoléin-1-one chlorhydrate

(3aS)-2-(S)-1-Azabicyclo[2,2,2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(d)isoquinolin-1-one

(3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isochinolin-1-onhydrochlorid

1H-benz[de]isoquinolin-1-one, 2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-, (3aS)-, monohydrochloride

(3aS)-2-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride (1:1)

1H-Benz[de]isoquinolin-1-one, 2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-, (3aS)-, hydrochloride (1:1)

Palonosetron (Hydrochloride)

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盐酸帕洛诺司琼

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