盐酸曲普利啶

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中文名	盐酸曲普利啶
英文名	triprolidine hydrochloride monohydrate
英文别名	更多

描述

盐酸曲普利啶是一种口服活性、细胞渗透性和第一代组胺H1拮抗剂[1]。盐酸曲普利啶是一种抗组胺药，可用于过敏性鼻炎、哮喘和荨麻疹[2]。

相关类别

信号通路 >>

免疫及炎症 >>

组胺受体

研究领域 >>

神经疾病

信号通路 >>

G 蛋白偶联受体/G 蛋白 >>

组胺受体

靶点

H1 Receptor

体内研究

曲普利啶（间隔内注射；0.5μl中0.5μM；破伤风后30、60和180 min）对基线fEPSPs没有显著影响，但是，与盐水注射（60 min时为208%）相比，步行时诱导的长时程增强（LTP）较小（60 min时为基线值的173%）[2]。动物模型：成年雄性Long-Evans TMN（tuberomamillary nucleus，TMN）损伤大鼠[2]剂量：0.5μl给药0.5μm：间隔内灌注；破伤风后30、60、180min结果：LTP的步行相关增强减弱。

存储

粉末	-20°C	3年
?	4°C	2年
在溶剂中	-80°C	6月
?	-20°C	1月

运输

室温

SMILES

CC1=CC=C(/C(C2=NC=CC=C2)=CCN3CCCC3)C=C1.[H]Cl.[H]O[H]

参考文献

[1]. Tao Luo, et al. Endogenous Histamine Facilitates Long-Term Potentiation in the Hippocampus During WalkingJ Neurosci. 2010 Jun 9;30(23):7845-52.

[2]. Sang-Chul Shin, et al. Controlled Release of Triprolidine Using Ethylene-Vinyl Acetate Membrane and Matrix Systems. Eur J Pharm Biopharm

沸点	462?C at 760 mmHg
熔点	115-120?C
分子式	C₁₉H₂₅ClN₂O
分子量	314.85200
闪点	233.2?C
精确质量	314.15500
PSA	16.13000
LogP	4.65740
外观性状	白色结晶粉末
储存条件	2-8°C
稳定性	Stable, but discolours in light. Incompatible with strong oxidizing agents.
水溶解性	>=10 g/100 mL at 20 ?C

盐酸曲普利啶MSDS英文版

盐酸曲普利啶毒性英文版

符号	GHS07
信号词	Warning
危害声明	H302-H315-H319-H335
警示性声明	P301 + P312 + P330-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xn:Harmful;
风险声明 (欧洲)	R22;R36/37/38
安全声明 (欧洲)	S26-S36
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	UT7658000

Involvement of histaminergic inputs in the jaw-closing reflex arc.

J. Neurophysiol. 113 , 3720-35, (2015)

Histamine receptors are densely expressed in the mesencephalic trigeminal nucleus (MesV) and trigeminal motor nucleus. However, little is known about the functional roles of neuronal histamine in cont…

Development and validation of an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistaminics in dietary supplements.

Biomed. Chromatogr. 29(3) , 465-74, (2015)

The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The l…

Quantification of antihistamine acrivastine in plasma by solid-phase extraction and high-performance liquid chromatography.

J. Pharm. Biomed. Anal. 43(1) , 293-7, (2007)

An automated solid-phase extraction method was developed for the determination of the H1-antihistamine acrivastine in plasma samples. Acrivastine was analyzed at the wavelength of 254 nm using a rever…

MFCD00150574

Triprolidine hydrochloride

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盐酸曲普利啶

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