盐酸替罗非班

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中文名	盐酸替罗非班
英文名	tirofiban hydrochloride
中文别名	替罗非班盐酸盐水合物 \| N-(正丁基磺酰基)-O-[4-(4-哌啶基)丁基]-L-酪氨酸盐酸盐水合物 \| 盐酸替罗非班
英文别名	更多

描述

Tirofiban盐酸盐一水合物是非肽类，糖蛋白IIb/IIIa拮抗剂。

相关类别

信号通路 >>

细胞骨架 >>

Integrin

研究领域 >>

心血管疾病

溶解度

体外：

DMSO：12 mg / mL（24.24 mM;需要超声波和加热）

储备液

1 mM	2.0199 mL	10.0996 mL	20.1992 mL
5 mM	0.4040 mL	2.0199 mL	4.0398 mL
10 mM	0.2020 mL	1.0100 mL	2.0199 mL

存储

粉末	-20℃下	3年
	4℃下	2年
在溶剂中	-80℃下	6个月
	-20℃下	1个月

运输

室温;可能会有所不同

SMILES

O=S(N[C@H](C(O)=O)CC1=CC=C(OCCCCC2CCNCC2)C=C1)(CCCC)=O.[H]Cl.[H]O[H]

参考文献

[1]. Winter JP, Juergens CP. The role of tirofiban in the management of coronary artery disease. Cardiovasc Hematol Disord Drug Targets. 2008 Jun;8(2):138-46.

[2]. van ‘t Hof AW, Valgimigli M. Defining the role of platelet glycoprotein receptor inhibitors in STEMI: focus on tirofiban. Drugs. 2009;69(1):85-100.

[3]. Valgimigli M, Biondi-Zoccai G, Tebaldi M et al. Tirofiban as adjunctive therapy for acute coronary syndromes and percutaneous coronary intervention: a meta-analysis of randomized trials. Eur Heart J. 2010 Jan;31(1):35-49.

[4]. Valgimigli M, Tebaldi M. Safety evaluation of tirofiban. Expert Opin Drug Saf. 2010 Sep;9(5):801-19.

[5]. Diaz JF, Cardenal R, Gomez-Manchero A, Sanchez-Gonzalez C. Safety and efficacy of tirofiban as adjunctive therapy for patients with ST-elevation myocardial infarction: a comparison versus placebo and abciximab. Cardiovasc Hematol Agents Med Chem. 2011 Jul 1;9(3):147-53.

相关活性
小分子

沸点	611.7?C at 760 mmHg
熔点	135-137?C
分子式	C₂₂H₃₉ClN₂O₆S
分子量	495.073
闪点	323.7?C
精确质量	494.221741
PSA	122.34000
LogP	5.48870
外观性状	白色固体
储存条件	-20°C Freezer
水溶解性	DMSO: >12mg/mL at warmed to 60°C

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335
警示性声明	P261-P305 + P351 + P338
危害码 (欧洲)	Xi
风险声明 (欧洲)	36/37/38
安全声明 (欧洲)	26-37-45
危险品运输编码	NONH for all modes of transport

Influence of Body Mass Index on the Activated Clotting Time Under Weight-Based Heparin Dose.

J. Clin. Lab Anal. 30 , 108-13, (2016)

Activated clotting time (ACT) has been successfully applied during percutaneous coronary intervention (PCI) to monitor the extent of thrombin inhibition and anti-coagulation from unfractionated hepari…

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盐酸替罗非班

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