盐酸枢复宁

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中文名	盐酸枢复宁
英文名	ondansetron hydrochloride
中文别名	盐酸昂丹司琼 \| 帕罗西汀杂质A
英文别名	更多

描述

Ondansetron盐酸盐是5-HT3受体拮抗剂，可作为化疗后止吐剂。

相关类别

信号通路 >>

G 蛋白偶联受体/G 蛋白 >>

5-HT受体

信号通路 >>

神经信号通路 >>

5-HT受体

研究领域 >>

神经疾病

溶解度

体外：

在DMSO中10mM

储备液

1 mM	3.0320 mL	15.1598 mL	30.3196 mL
5 mM	0.6064 mL	3.0320 mL	6.0639 mL
10 mM	0.3032 mL	1.5160 mL	3.0320 mL

存储

请将产品存放在分析证书中的建议条件下。

运输

室温;可能会有所不同

SMILES

O=C1C(CN2C=CN=C2C)CCC(N3C)=C1C4=C3C=CC=C4.[H]Cl

参考文献

[1]. Brown AM, et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar 15;507 ( Pt 3):653-65.

[2]. Barann M, et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362(3):255-65.

[3]. Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50.

[4]. Khedhaier A, et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20(6):1103-16.

[5]. Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb;20(1):78-83.

[6]. Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf. 2013 May;12(3):421-31.

相关活性
小分子

密度	1.27g/cm3
沸点	546?C at 760mmHg
熔点	178.5-179.5?C
分子式	C₁₈H₂₀ClN₃O
分子量	329.824
闪点	284?C
精确质量	329.129486
PSA	39.82000
LogP	3.93050
外观性状	白色粉末
储存条件	?20°C
水溶解性	H2O: >5?mg/mL

危害码 (欧洲)	T: Toxic;
风险声明 (欧洲)	R25
安全声明 (欧洲)	45-37/39-26
危险品运输编码	UN 2811 6
WGK德国	3
RTECS号	FE6375500
包装等级	II
危险类别	6.1(a)
海关编码	29339900

昂丹司琼

99614-02-5

~90%

盐酸枢复宁

99614-01-4

文献：WO2005/37822 A1, ; Page/Page column 12 ;

2-甲基咪唑

693-98-1

1,2,3,9-四氢-9-甲基咔唑酮

27387-31-1

四甲基甲烷二胺

51-80-9

~78%

盐酸枢复宁

99614-01-4

文献：WO2005/37822 A1, ; Page/Page column 12 ;

1,2,3,9-tetrahy…

99614-60-5

~93%

盐酸枢复宁

99614-01-4

文献：YUHAN CORPORATION Patent: ? WO2005/37822?A1, 2005 ; Location in patent: Page/Page column 12 ;

盐酸枢复宁上游产品? 4
CAS号99614-02-5 昂丹司琼 CAS号27387-31-1 1,2,3,9-四氢-9-甲基咔唑酮 CAS号51-80-9 四甲基甲烷二胺 CAS号99614-60-5 1,2,3,9-tetrahy…
盐酸枢复宁下游产品? 2
CAS号99614-02-5 昂丹司琼 CAS号99614-60-5 1,2,3,9-tetrahy…

盐酸枢复宁上游产品? 4

CAS号99614-02-5
昂丹司琼

CAS号27387-31-1
1,2,3,9-四氢-9-甲基咔唑酮

CAS号51-80-9
四甲基甲烷二胺

CAS号99614-60-5
1,2,3,9-tetrahy…

盐酸枢复宁下游产品? 2

CAS号99614-02-5
昂丹司琼

CAS号99614-60-5
1,2,3,9-tetrahy…

UNII:2999F27MAD

(R)-Ondansetron Hydrochloride Dihydrate

4H-CARBAZOL-4-ONE,1,2,3,9-TETRAHYDRO-9-METHYL-3-[(2-METHYL-1H-IMIDAZOL-1-YL)METHYL]-,HYDROCHLORIDE (1:1)

9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one

LSUREMONOETHANOLAMID

Ondansetron HCl

1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride

OEA,oleoylethanolamide

N-(Hydroxyethyl)oleamide

9-Methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride

[3H]-Oleoylethanolamide

oleic acid ethanolamide

ONDANSETRON HCL DIHYDRATE

9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4h-carbazol-4-onhydrochlorid

Ondansetron HCl (Zofran)

4H-carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, monohydrochloride

oleic monoethanolamide

Ondansetron (hydrochloride)

ONDANSETRONHYDROCHLORIDE

ONDANSETRON HCL DIHYDRATE IMP. E (EP): 1H-IMIDAZOLE, CRM STANDARD

Ondansetron hydrochloride (Zofran)

oleic acid-N-monoethanolamide

N-(2-Hydroxyethyl)oleamide

OEA

Oleoylethanolamide

[3H]-Ondansetron hydrochloride

4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, hydrochloride (1:1)

ODANSETRON HYDROCHLORIDE DIHYDRATE

Ondansetron Hydrochloride

Oleyl monoethanolamide

OLEAMIDE MEA

9-méthyl-3-[(2-méthyl-1H-imidazol-1-yl)méthyl]-1,2,3,9-tétrahydro-4H-carbazol-4-one chlorhydrate

Oleoylmonoethanolamide

9-Methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride (1:1)

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盐酸枢复宁

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