盐酸氨溴索

中文名	盐酸氨溴索
英文名	Ambroxol hydrochloride
中文别名	2-氨基-3,5-二溴-N-(反式-4-羟基环己基)苄胺
英文别名	更多

描述

Ambroxol hydrochloride (NA-872 hydrochloride) 是前药溴己辛的活性代谢产物，具有强效祛痰作用。Ambroxol hydrochloride 是一种葡糖脑苷脂酶 (GCase) 伴侣，可增加葡糖脑苷脂酶的活性。Ambroxol hydrochloride 可诱导肺自噬，并有用于帕金森氏病和神经性戈谢病研究的潜力。

相关类别

信号通路 >>

自噬 >>

自噬

研究领域 >>

代谢疾病

研究领域 >>

神经疾病

体内研究

在转基因小鼠脑组织中，连续表达糖甙酶871-2天，转基因小鼠脑组织糖酶活性增加。

储备液

1 mM	2.4122 mL	12.0610 mL	24.1220 mL
5 mM	0.4824 mL	2.4122 mL	4.8244 mL
10 mM	0.2412 mL	1.2061 mL	2.4122 mL

运输

室温

SMILES

O[C@H]1CC[C@H](NCC2=CC(Br)=CC(Br)=C2N)CC1.[H]Cl

参考文献

[1]. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218.

[2]. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775.

沸点	468.6?C at 760 mmHg
熔点	235 – 240?C
分子式	C₁₃H₁₉Br₂ClN₂O
分子量	414.564
闪点	237.2?C
精确质量	411.955261
PSA	58.28000
LogP	4.96100
外观性状	白色至淡黄色结晶粉末
储存条件	库房通风低温干燥

盐酸氨溴索MSDS英文版

盐酸氨溴索毒性英文版

个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	R22
安全声明 (欧洲)	36
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	GV8423000
海关编码	2922199090

海关编码	2922199090
中文概述	2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Gastro retention using polymer cocoons.

Artif. Cells. Nanomed. Biotechnol. 43(1) , 26-32, (2015)

A gastro-retentive capsule has been prepared which is retained in the stomach for a period of 24h, providing a vehicle for the controlled delivery to the upper intestines. These “gastro cocoons” can r…

Enzyme enhancers for the treatment of Fabry and Pompe disease.

Mol. Ther. 23(3) , 456-64, (2015)

Lysosomal storage disorders (LSD) are a group of heterogeneous diseases caused by compromised enzyme function leading to multiple organ failure. Therapeutic approaches involve enzyme replacement (ERT)…

Jauch, R., et al.

Arzneimittelforschung 13 , 474, (1963)

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EINECS 245-899-2

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FRENOPECT

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