盐酸石蒜碱

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中文名	盐酸石蒜碱
英文名	Lycorine hydrochloride
中文别名	石蕊碱 \| 石蒜碱
英文别名	更多

描述

Lycorine (hydrochloride) 是一种 VE-cadherin 抑制剂,在 Hey1B细胞中的 IC50为1.2μM。

相关类别

信号通路 >>

自噬 >>

自噬

天然产物 >>

生物碱

研究领域 >>

癌症

溶解度

体外：

DMSO：≥31mg / mL（95.75 mM）

* “≥”表示可溶，但饱和度未知。

储备液

1 mM	3.0886 mL	15.4431 mL	30.8861 mL
5 mM	0.6177 mL	3.0886 mL	6.1772 mL
10 mM	0.3089 mL	1.5443 mL	3.0886 mL

存储

粉末	-20°C	3年
?	4°C	2年
在溶剂中	-80°C	6月
?	-20°C	1月

运输

室温;可能会有所不同

SMILES

O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(OCO5)C5=C4.Cl

参考文献

[1]. Liu, R. et al. Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry. Pigment cell & melanoma research 25, 630-638, doi:10.1111/j.1755-148X.2012.01036.x (2012).

[2]. Cao, Z. et al.Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity. Toxicology letters 218, 174-185, doi:10.1016/j.toxlet.2013.01.018 (2013).

相关活性
小分子

沸点	477.4?C at 760 mmHg
熔点	210-212?C
分子式	C₁₆H₁₈ClNO₄
分子量	323.77
闪点	242.5?C
PSA	62.16000
LogP	0.68650
外观性状	细晶体粉末
蒸汽压	6.37E-10mmHg at 25°C
储存条件	2-8°C

盐酸石蒜碱毒性英文版

符号	GHS06
信号词	Danger
危害声明	H301
警示性声明	P301 + P310
个人防护装备	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危害码 (欧洲)	T: Toxic;
风险声明 (欧洲)	R25
安全声明 (欧洲)	45
危险品运输编码	UN 2811

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盐酸石蒜碱

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