盐酸莫昔普利

USD$0.00

品牌商品推荐

更多 >>

尼罗替尼
棕榈酸
盐酸环胞苷
氨基磺酸镍
甲醛合次硫酸氢钠
花生四烯酸

商品详情

客户评价

中文名	盐酸莫昔普利
英文名	(3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid,hydrochloride
中文别名	(3S)-2-[(2S)-2-[[(1S)-1-(乙氧羰基)-3-苯基丙基]氨基]-1-氧代丙基]-1,2,3,4-四氢-6,7-二甲氧基-3-异喹啉羧酸盐酸盐 \| 2-[2-[(1-乙氧基甲酰-3-苯基丙基)氨基]丙酰基]-6,7-二甲氧基-3,4-二氢-1H-异喹啉-3-羧酸盐酸盐 \| 莫西普利盐酸盐
英文别名	更多

描述

Moexipril盐酸盐是口服活性的不含巯基的血管紧张素转化酶抑制剂，可作用于高血压和充血性心力衰竭。

相关类别

信号通路 >>

代谢酶/蛋白酶 >>

血管紧张素转换酶(ACE)

研究领域 >>

心血管疾病

溶解度

体外：

在DMSO中10mM

储备液

1 mM	1.8691 mL	9.3453 mL	18.6905 mL
5 mM	0.3738 mL	1.8691 mL	3.7381 mL
10 mM	0.1869 mL	0.9345 mL	1.8691 mL

存储

粉末	-20℃下	3年
	4℃下	2年
在溶剂中	-80℃下	6个月
	-20℃下	1个月

运输

室温;可能会有所不同

SMILES

O=C([C@H]1N(C([C@@H](N[C@H](C(OCC)=O)CCC2=CC=CC=C2)C)=O)CC3=C(C=C(OC)C(OC)=C3)C1)O.Cl

参考文献

[1]. Chrysant, S.G. and G.S. Chrysant, Pharmacological and clinical profile of moexipril: a concise review. J Clin Pharmacol, 2004. 44(8): p. 827-36.

[2]. Edling, O., et al., Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril. J Pharmacol Exp Ther, 1995. 275(2): p. 854-63.

[3]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24.

相关活性
小分子

沸点	709.3?C at 760 mmHg
熔点	141-161?C
分子式	C₂₇H₃₅ClN₂O₇
分子量	535.03
闪点	382.8?C
PSA	114.40000
LogP	3.71510
外观性状	一种细白色至灰白色粉末

符号	GHS09
信号词	Warning
危害声明	H400
警示性声明	P273
个人防护装备	Eyeshields;Gloves
危害码 (欧洲)	N:Dangerous for the environment
风险声明 (欧洲)	R50
安全声明 (欧洲)	60
危险品运输编码	UN 3077
RTECS号	NW7174500

[3S-[2[R*(R*)]]…

82586-51-4

~88%

盐酸莫昔普利

82586-52-5

文献：Klutchko; Blankley; Fleming; Hinkley; Werner; Nordin; Holmes; Hoefle; Cohen; Essenburg Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1953 – 1961

盐酸莫昔普利上游产品? 1
CAS号82586-51-4 [3S-[2[R(R)]]…
盐酸莫昔普利下游产品? 2
CAS号103775-14-0 莫昔普利拉 CAS号103733-51-3 莫西普利二酮哌嗪

盐酸莫昔普利上游产品? 1

CAS号82586-51-4
[3S-[2[R*(R*)]]…

盐酸莫昔普利下游产品? 2

CAS号103775-14-0
莫昔普利拉

CAS号103733-51-3
莫西普利二酮哌嗪

Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.

Clin. Pharmacol. Ther. 96(6) , 713-22, (2014)

Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) a…

Lymphatics in the human endometrium disappear during decidualization.

Hum. Reprod. 25 , 2455-64, (2010)

The mammalian placenta plays a central role in maternal tolerance of the semi-allogeneic fetus and fluid balance between the maternal and fetal compartments. The lymphatics play a role in both these f…

Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes.

EMBO J. 29 , 222-35, (2010)

It has been suggested that intrinsic brain tumours originate from a neural stem/progenitor cell population in the subventricular zone of the post-natal brain. However, the influence of the initial gen…

Uniretic

Univasc

SPM 925

Moexipril HCl

Moexipril HCL

MOEXIPRIL HYDROCHLORIDE

CI-925

UNII-Q1UMG3UH45

Moexipril (hydrochloride)

Tags:

This product was successfully added to cart!

盐酸莫昔普利

品牌商品推荐

尼罗替尼

棕榈酸

盐酸环胞苷

氨基磺酸镍

甲醛合次硫酸氢钠

花生四烯酸

商品详情

客户评价