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| 中文名 |
盐酸非索非那定 |
|---|---|
| 英文名 |
Fexofenadine Hydrochloride |
| 中文别名 |
非索非那定盐酸盐 | Benzeneacetic acid, 4-?[1-?hydroxy-?4-?[4-?(hydroxydiphenylmeth?yl)?-?1-?piperidinyl]?butyl]?-?α,?α-?dimethyl-?, hydrochloride |
| 英文别名 |
更多 |
| 描述 |
Fexofenadine是第三代抗组胺药，用于治疗过敏症状，如花粉热，鼻塞和荨麻疹。 |
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| 相关类别 |
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| 溶解度 |
体外：
DMSO：≥50mg / mL（92.92 mM） * “≥”表示可溶，但饱和度未知。
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| 储备液 |
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| 存储 |
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| 运输 |
室温;可能会有所不同 |
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| SMILES |
O=C(O)C(C)(C)C1=CC=C(C(O)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2)C=C1.[H]Cl |
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| 参考文献 |
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| 相关活性 小分子 |
氯雷他定 | 组胺 | 1-[3-[3-(4-氯丙基)丙氧基]丙基]-哌啶盐酸盐 | 西咪替丁 | 蛇床子素 | 富马酸氯马斯汀 | 乙溴替丁 | 1-[(5-氯-1H-吲哚-2-基)羰基]-4-甲基哌嗪 | 法莫替丁 | 盐酸西替利嗪 | 地氯雷他定 | 富马酸酮替芬 | 诺朵腊酸 | 盐酸美克洛嗪 | 扑尔敏 |
| 熔点 | 148-150oC |
|---|---|
| 分子式 | C32H40ClNO4 |
| 分子量 | 538.117 |
| 精确质量 | 537.264587 |
| PSA | 81.00000 |
| LogP | 6.25040 |
| 外观性状 | 固体;White to Almost white powder to crystal |
| 储存条件 | ?20°C |
| 水溶解性 | 可溶于：甲醇 |
| 个人防护装备 |
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 危害码 (欧洲) |
Xi |
| 风险声明 (欧洲) |
36/37/38 |
| 安全声明 (欧洲) |
26-36 |
| 危险品运输编码 | NONH for all modes of transport |
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Histamine and TGF-β, major mediators secreted by mast cells, are involved in skin inflammation and play critical roles in the pathogenesis of systemic sclerosis. However, the roles of signaling mechan…
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Probiotic properties of lactic acid bacteria isolated from water-buffalo mozzarella cheese. Probiotics Antimicrob Proteins 6 , 141-56, (2014)
This study evaluated the probiotic properties (stability at different pH values and bile salt concentration, auto-aggregation and co-aggregation, survival in the presence of antibiotics and commercial…
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Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1. Pharm. Res. 31(8) , 2035-43, (2014)
OATP2B1-mediated grapefruit juice (GFJ)-drug interactions are substrate-dependent; for example, GFJ ingestion significantly reduces bioavailability of fexofenadine, but not pravastatin. In the present…
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2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropans?urehydrochlorid |
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Fexofenidine hydrochloride MDL 16455 hydrochloride Terfenidine carboxylate hydrochloride |
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Benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride (1:1) |
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Fexofenadine HCl |
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Fexofenadine hydrochloride |
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benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-, hydrochloride |
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Fexofenidine hydrochloride,MDL 16455 hydrochloride,Terfenidine carboxylate hydrochloride |
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2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid hydrochloride (1:1) |
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acide 2-[4-(1-hydroxy-4-{4-[hydroxy(diphényl)méthyl]pipéridin-1-yl}butyl)phényl]-2-méthylpropano?que chlorhydrate |
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MFCD08064193 |
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UNII:2S068B75ZU |
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2-[4-(1-hydroxy-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butyl)phenyl]-2-methylpropanoic acid hydrochloride |
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2-[4-(1-Hydroxy-4-{4-[hydroxy(diphenyl)methyl]-1-piperidinyl}butyl)phenyl]-2-methylpropanoic acid hydrochloride (1:1) |
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benzeneacetic acid, 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-a,a-dimethyl-, hydrochloride (1:1) |
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Benzeneacetic acid, 4-?[1-?hydroxy-?4-?[4-?(hydroxydiphenylmeth?yl)?-?1-?piperidinyl]?butyl]?-?α,?α-?dimethyl-?, hydrochloride |
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Fexofenadine (hydrochloride) |
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