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知母皂苷BIII

知母皂苷BIII

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?知母皂苷BIII名称


















中文名

知母皂苷B
英文名

pseudoprototimosaponin AIII
中文别名


知母皂苷BIII



英文别名
更多





?知母皂苷BIII生物活性


































描述
Timosaponin B III 是一种主要的生物活性甾体皂苷，从知母中分离出来，具有抗炎、抗血小板聚集和抗抑郁作用。
相关类别




SMILES

C[C@@]12[C@](C[C@@]3([H])[C@]2([H])C(C)=C(CC[C@H](C)CO[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO)O3)([H])[C@@]5([H])[C@]([C@@]6([C@](C[C@@H](O[C@@]7([H])[C@@H]([C@H]([C@@H](O)[C@@H](CO)O7)O)O[C@]8([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]8O)CO)CC6)([H])CC5)C)([H])CC1
参考文献

[1]. Zhang XL, et al. Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity. Exp Ther Med. 2017 Oct;14(4):3856-3861.

[2]. Zhao YF, et al. New transformation pathway and cytotoxic derivatives from the acid hydrolysis of timosaponin B III. Nat Prod Res. 2018 Nov 20:1-7.

[3]. Kang LP, et al. Steroidal glycosides from the rhizomes of Anemarrhena asphodeloides and their antiplateletaggregation activity. Planta Med. 2012 Apr;78(6):611-6.






?知母皂苷BIII物理化学性质



































密度 1.4±0.1 g/cm3
沸点 1023.7±65.0 °C at 760 mmHg
分子式 C45H74O18
分子量 903.058
闪点 572.9±34.3 °C
精确质量 902.487488
PSA 287.14000
LogP 2.01
蒸汽压 0.0±0.6 mmHg at 25°C
折射率 1.626
















?知母皂苷BIII英文别名

































β-D-Galactopyranoside, (3β,5β,25S)-26-(β-D-glucopyranosyloxy)furost-20(22)-en-3-yl 2-O-β-D-glucopyranosyl-


(3β,5β,25S)-26-(β-D-Glucopyranosyloxy)furost-20(22)-en-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside


anemarrhenasaponin IV


timosaponin B-III


timosaponin B


timosaponin BIII


timosaponin B III


anemarsaponin BIII








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