硝酸芬替康唑

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中文名	硝酸芬替康唑
英文名	fenticonazole nitrate
中文别名	1-[2-(2,4-二氯苯基)-2-[[4-(苯硫代)苯基]甲氧基]乙基]-1H-咪唑硝酸盐 \| 1-[2-(2,4-二氯苯基)-2-[(4-苯基硫苯基)甲氧基]乙基]咪唑硝酸盐 \| 硝酸芬康唑
英文别名	更多

描述

Fenticonazole硝酸盐是抗真菌化合物。

相关活性
小分子

密度	1.26g/cm3
沸点	637.2?C at 760 mmHg
熔点	135-137?C
分子式	C₂₄H₂₁Cl₂N₃O₄S
分子量	518.412
闪点	339.2?C
精确质量	517.062988
PSA	118.40000
LogP	7.47470
折射率	1.632
储存条件	Refrigerator
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:1 3.氢键受体数量:6 4.可旋转化学键数量:8 5.互变异构体数量:无 6.拓扑分子极性表面积118 7.重原子数量:34 8.表面电荷:0 9.复杂度:524 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:1 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:2
更多	1.性状：白色结晶性粉末，无臭。 2.熔点：136℃。 3.溶解度：在20℃时的溶解度(mg/m1)：水＜0.1。乙醚＜0.1，乙醇30，氯仿300，二甲基甲酰胺600。 4.UV最大吸收(甲醇)：252nm(ε13894)。 5.pKa：6.54。

硝酸芬替康唑毒性英文版

危害码 (欧洲)	Xi,Xn
风险声明 (欧洲)	R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
安全声明 (欧洲)	S26
海关编码	2942000000

2,4-二氯苯-α-氯乙酮经氢硼化钠还原后，先和咪唑缩合，再和4-氯甲基二苯硫醚缩合，即得芬康唑。 73151-29-8 preparation

海关编码	2942000000

In vitro activity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates of Candida albicans and Candida spp.

Mycopathologia 118(1) , 15-21, (1992)

The in vitro activity of several new imidazoles, cloconazole, sulconazole, butoconazole, isoconazole and fenticonazole, were compared with those of amphothericin B, flucytosine, and three azoles: econ…

Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes.

Antimicrob. Agents Chemother. 53 , 2181-4, (2009)

The activity of fenticonazole was studied against 260 West and Southeast European vulvovaginal candidiasis isolates, and low MICs were displayed. Fenticonazole was assessed by European Committee on An…

Single dose therapy of vaginal candidiasis: a comparative trial of fenticonazole vaginal ovules versus clotrimazole vaginal tablets.

Curr. Med. Res. Opin. 12(2) , 114-20, (1990)

An open, randomized comparative clinical trial was performed in 153 patients suffering from symptomatic vaginal candidiasis confirmed by mycological tests. Patients were allocated at random into two g…

1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-, nitrate (1:1)

Lomexin

EINECS 277-302-6

1-[2-(2,4-dichlorophenyl)-2-[(4-phenylsulfanylphenyl)methoxy]ethyl]imidazole,nitric acid

MFCD00941391

Falvin

REC 15/1476

Fenticonazole nitrate (USAN)

Fenticonazole (Nitrate)

Fenticonazole mononitrate

1-(2-(2,4-Dichlorophenyl)-2-((4-(phenylthio)phenyl)methoxy)ethyl)-1H-imidazolium nitrate

1-[2-(2,4-Dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]-1H-imidazol-1-ium nitrate

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硝酸芬替康唑

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