中文名 |
硫酸丁胺卡那霉素 |
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英文名 |
amikacin disulfate |
中文别名 |
硫酸阿米卡星 | 硫酸阿米卡星 | O-3-氨基-3-脱氧-alpha-D-葡吡喃糖基-(1→6)-O-[(6-氨基-6-脱氧-alpha-D-葡吡喃糖基-(1→4)]-N-(4-氨基-2-羟基-1-氧丁基)-2-脱氧-D-链霉胺硫酸盐 | 地佐环平 |
英文别名 |
更多 |
描述 |
Amikacin硫酸盐(BAY416651)是半合成氨基葡萄糖苷抗生素,卡那霉素A衍生物。 |
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相关类别 |
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溶解度 |
体外:
H 2 O:≥50mg / mL(63.96 mM) * “≥”表示可溶,但饱和度未知。
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储备液 |
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存储 |
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运输 |
室温;可能会有所不同 |
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SMILES |
OS(O)(=O)=O.OS(O)(=O)=O.O[C@@H]1[C@H]([C@@H](C[C@H](N)[C@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CN)NC([C@@H](O)CCN)=O)O[C@@]([C@@H]([C@@H](N)[C@@H]3O)O)([H])O[C@@H]3CO |
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参考文献 |
[1]. Edson, R.S. and C.L. Terrell, The aminoglycosides. Mayo Clin Proc, 1999. 74(5): p. 519-28.
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相关活性 小分子 |
嘌呤霉素盐酸盐 | G-418 硫酸盐 | 衣霉素 | 潮霉素B | 盐霉素 | 阿维巴坦钠 | 硫酸新霉素 | 法硼巴坦 | 甲氧西林钠 | 利福平 | 甲硝唑 | 羧苄青霉素钠 | 头孢他啶 | Eravacycline dihydrochloride | 头孢噻肟钠 |
沸点 | 981.8?C at 760 mmHg |
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熔点 | 220-230?C |
分子式 | C22H47N5O21S2 |
分子量 | 781.760 |
精确质量 | 781.220520 |
PSA | 497.90000 |
外观性状 | 固体 |
储存条件 |
密封、阴凉、干燥保存 |
稳定性 |
常规情况下不会分解,没有危险反应 |
水溶解性 | H2O: 50?mg/mL, clear, colorless |
更多 |
1. 性状:粉末 2. 密度(g/mL,25 ?C):未确定 3. 相对蒸汽密度(g/mL,空气=1): 未确定 4. 熔点(?C):220-230 5. 沸点(?C):未确定 6. 沸点(?C,12mm hg):未确定 7. 折射率:未确定 8. 闪点(?C):未确定 9. 比旋光度(?):未确定 10. 自燃点或引燃温度(?C): 未确定 11. 蒸气压(kPa,25?C):未确定 12. 饱和蒸气压(kPa,60?C): 未确定 13. 燃烧热(KJ/mol):未确定 14. 临界温度(?C):未确定 15. 临界压力(KPa):未确定 16. 油水(辛醇/水)分配系数的对数值:未确定 17. 爆炸上限(%,V/V):未确定 18. 爆炸下限(%,V/V):未确定 19. 溶解性:可溶解的 |
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硫酸丁胺卡那霉素毒性英文版
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个人防护装备 |
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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危害码 (欧洲) |
Xi |
风险声明 (欧洲) |
R36/37/38 |
安全声明 (欧洲) |
26-36 |
危险品运输编码 | NONH for all modes of transport |
WGK德国 | 2 |
RTECS号 | WK1961200 |
海关编码 | 29419000 |
Nitrotriazole- and imidazole-based amides and sulfonamides as antitubercular agents. Antimicrob. Agents Chemother. 58(11) , 6828-36, (2014)
Twenty-three 3-nitrotriazole-based and 2-nitroimidazole-based amides and sulfonamides were screened for antitubercular (anti-TB) activity in aerobic Mycobacterium tuberculosis H37Rv by using the BacTi…
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Simple and accurate quantitative analysis of 20 anti-tuberculosis drugs in human plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry. J. Pharm. Biomed. Anal. 102 , 9-16, (2014)
A simple and accurate liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method for the quantitation of 20 anti-tuberculosis (anti-TB) drugs in human plasma, was developed as a tool for thera…
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Interactions of amikacin with the RNA model of the ribosomal A-site: computational, spectroscopic and calorimetric studies. Biochimie 102 , 188-202, (2014)
Amikacin is a 2-deoxystreptamine aminoglycoside antibiotic possessing a unique l-HABA (l-(-)-γ-amino-α-hydroxybutyric acid) group and applied in the treatment of hospital-acquired infections. Amikacin…
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2-[(3-aminopropyl)amino]ethylphosphorothioic acid monohydrate |
Amifostina |
Amifostinum |
Amikacin disulfate salt |
EINECS 254-648-6 |
D-Streptamine |
amikacin disulphate |
Amikacin Sulphate |
MFCD00167475 |
amifostine monohydrate |
Butanamide, 4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-β-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl]-2-hydroxy-, (2S)-, sulfate (1:2) (sa lt) |
Amifostine hydrate |
amikacin disulfate |
Butanamide, 4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl]-2-hydroxy-, (2S)-, sulfate (1:2) (s alt) |
(2S)-4-Amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-β-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide sulfate (1:2) |
(2S)-4-Amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide sulfate (1:2) |
Amikacin sulfate |
Amikacin (sulfate) |