硫酸奎尼丁二水合物

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中文名	硫酸奎尼丁二水合物
英文名	Quinidine sulfate salt dihydrate
中文别名	奎尼定硫酸盐 \| 硫酸奎尼丁 \| 硫酸奎尼丁
英文别名	更多

描述	Quinidine sulfate dihydrate 是一种有效且选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，可在体内抑制苯丙胺的代谢。Quinidine sulfate dihydrate 增强长春新碱 (VCR) 在肿瘤细胞中的细胞毒性，尤其是在 P388 白血病 (P388/VCR) 和人骨髓性白血病的VCR 耐药亚型中。
相关类别	研究领域 >> 癌症信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450
靶点	IC50: cytochrome P450db; amphetamine metabolism[1]
SMILES	O=S(O)(O)=O.[H]O[H].C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2(C)[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34.[0.5]
参考文献	[1]. David E. Moody, et al. Quinidine Inhibits In Vivo Metabolism of Amphetamine in Rats: Impact upon Correlation between GCIMS and Immunoassay Findings in Rat Urine. ournal of Analytical Toxicology, Vol. 14, September/October 1990 [2]. Tsuruo T, et al. Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.Cancer Res. 1984 Oct;44(10):4303-7.

沸点	992.5?C at 760 mmHg
熔点	212-214?°C (dec.)(lit.)
分子式	C₂₀H₂₄N₂O_2.1/₂H₂O₄S_.H₂O
分子量	782.943
闪点	554?C
精确质量	782.356079
PSA	192.62000
LogP	6.52160
折射率	275 ° (C=2, 0.1mol/L HCl)

硫酸奎尼丁二水合物MSDS英文版

硫酸奎尼丁二水合物毒性英文版

符号	GHS07
信号词	Warning
危害声明	H302
警示性声明	P301 + P312 + P330
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xn
风险声明 (欧洲)	R22
安全声明 (欧洲)	13-36
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	VA5605000

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Aliskiren is a substrate for P-glycoprotein (P-gp) and is metabolized via cytochrome P450 3A4 (CYP3A4). The aim of the present study was to assess whether P-gp influenced the pharmacokinetics of alisk…

Quinidine Sulfate Dihydrate

Cinchonan-9-ol, 6′-methoxy-, (9S)-, sulfate, hydrate (2:1:2) (salt)

EINECS 200-046-3

(9S)-6′-Methoxycinchonan-9-ol sulfate hydrate (2:1:2)

MFCD00149346

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硫酸奎尼丁二水合物

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