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硫酸西梭霉素
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商品详情
客户评价
| 描述 |
Sisomicin硫酸盐是一种氨基糖苷类抗生素。 |
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| 相关类别 |
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| 溶解度 |
体外：
H 2 O：20 mg / mL（28.87 mM;需要超声波和加温）
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| 储备液 |
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| 存储 |
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| 运输 |
室温;可能会有所不同 |
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| SMILES |
N[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@@](O)(C)[C@H](NC)[C@H]3O)[C@H]2O)([H])OC(CN)=CC1.[2.5H2SO4] |
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| 相关活性 小分子 |
嘌呤霉素盐酸盐 | G-418 硫酸盐 | 衣霉素 | 潮霉素B | 盐霉素 | 阿维巴坦钠 | 硫酸新霉素 | 法硼巴坦 | 甲氧西林钠 | 利福平 | 甲硝唑 | 羧苄青霉素钠 | 头孢他啶 | Eravacycline dihydrochloride | 头孢噻肟钠 |
| 沸点 | 676.6?C at 760mmHg |
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| 熔点 | 70-73?C |
| 分子式 | C19H37N5O7 . 5/2 H2SO4 |
| 分子量 | 692.72 |
| 闪点 | 363?C |
| PSA | 842.34000 |
| LogP | 0.82120 |
| 外观性状 | white to off-white |
| 储存条件 | 库房通风低温干燥,与食品原料分开存放 |
| 水溶解性 | H2O: soluble50mg/mL | Soluble in water |
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硫酸西梭霉素毒性英文版
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| 符号 |
GHS07, GHS08 |
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| 信号词 |
Danger |
| 危害声明 |
H312 + H332-H360 |
| 警示性声明 |
P201-P261-P280-P308 + P313 |
| 个人防护装备 |
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| 危害码 (欧洲) |
T,Xi |
| 风险声明 (欧洲) |
61-20/21/22-36/37/38 |
| 安全声明 (欧洲) |
53-22-36/37/39-45-36-26 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
| RTECS号 | WK2288000 |
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Determination of equilibrium constant of amino carbamate adduct formation in sisomicin by a high pH based high performance liquid chromatography. J. Pharm. Biomed. Anal. 111 , 126-30, (2015)
Amino carbamate adduct formation from the amino group of an aminoglycoside and carbon dioxide has been postulated as a mechanism for reducing nephrotoxicity in the aminoglycoside class compounds. In t…
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Biomimetic synthesis and structural refinement of the macrocyclic dimer aminoglycoside 66-40C–the remarkably selective self-condensation of a putative aldehyde intermediate in the submerged culture medium producing sisomicin. Chem. Commun. (Camb.) 46(12) , 2013-5, (2010)
Aminoglycoside 66-40C, an unprecedented 16-membered bis-azadiene macrocyclic natural product isolated from the Micromonospora producer of the antibiotic sisomicin, was synthesized following a biomimet…
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Pharmacokinetics and safety of single and multiple doses of ACHN-490 injection administered intravenously in healthy subjects. Antimicrob. Agents Chemother. 55(12) , 5874-80, (2011)
ACHN-490 is an aminoglycoside with activity against multidrug-resistant pathogens, including those resistant to currently used aminoglycosides. Two randomized, double-blind, placebo-controlled clinica…
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Extramycin |
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Siseptin |
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Pathomycin |
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sisomicin sulfate |
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Antibiotic 66-40 sulfate |
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O-3-Deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl(1?6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1?4)]-2-deoxy-D-streptamine Sulfate (2:5) (Salt) |
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Sch 13475 sulfate |
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(1S,2S,3R,4S,6R)-4,6-Diamino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranoside sulfate (2:5) |
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(2S-cis)-4-O-[3-Amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]-2-deoxy-6-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl]-D-streptamine Sulfate (2:5) (Salt) |
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Mensiso |
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Sisomycin sulfate |
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Sisomin |
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β-L-Arabinopyranoside, (1S,2S,3R,4S,6R)-4,6-diamino-3-[[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-, sulfate (2:5) (salt) |
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