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胡黄连苷I
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| 描述 |
Picroside I 是 Picrorhiza kurroa 的一种主要成分。Picrorhiza kurroa 是一种高价值的药用植物，富含肝脏保护代谢物 Picroside I 和 Picroside-II。Picroside I 是一种哮喘治疗药物。Picroside I 可显着减轻炎症。Picroside I 还下调 pSTAT6 和 GATA3 表达。Picroside I 剂量依赖性地增加血清 IFN-γ 水平。 |
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| 相关类别 |
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| 靶点 |
STAT6
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| SMILES |
OC[C@]12[C@@H](O2)[C@@H](O)[C@@]3([H])[C@]1([H])[C@H](O[C@]4([H])O[C@H](COC(/C=C/C5=CC=CC=C5)=O)[C@@H](O)[C@H](O)[C@H]4O)OC=C3 |
| 参考文献 |
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| 密度 | 1.6±0.1 g/cm3 |
|---|---|
| 沸点 | 739.1±60.0 °C at 760 mmHg |
| 熔点 | 130 °C |
| 分子式 | C24H28O11 |
| 分子量 | 492.473 |
| 闪点 | 253.2±26.4 °C |
| 精确质量 | 492.163147 |
| PSA | 167.67000 |
| LogP | -1.81 |
| 外观性状 | 固体;White to Almost white powder to crystal |
| 蒸汽压 | 0.0±2.6 mmHg at 25°C |
| 折射率 | 1.671 |
| 储存条件 | 2-8°C |
| 水溶解性 | ethanol: soluble1mg/mL, clear, colorless |
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Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells. Eur. J. Pharmacol. 406(2) , 203-8, (2000)
Natural iridoid, picroside I (beta-D-glucopyranoside, 1a,1b,2,5a,6, 6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1, 2-c]pyran-2-yl, 6-(3-phenyl-2-propenoate)) or II (beta-D-glucopyr…
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Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells. Life Sci. 71(15) , 1821-35, (2002)
Picrosides I and II caused a concentration-dependent (> 0.1 microM) enhancement of basic fibroblast growth factor (bFGF, 2 ng/ml)-, staurosporine (10 nM)- and dibutyryl cyclic AMP (dbcAMP, 0.3 mM)-ind…
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De novo sequencing and characterization of Picrorhiza kurrooa transcriptome at two temperatures showed major transcriptome adjustments. BMC Genomics 13 , 126, (2012)
Picrorhiza kurrooa Royle ex Benth. is an endangered plant species of medicinal importance. The medicinal property is attributed to monoterpenoids picroside I and II, which are modulated by temperature…
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picroside-1 |
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PicrosideI |
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2-Propenoic acid, 3-phenyl-, (1aS,1bS,2S,5aR,6S,6aS)-2-(β-D-glucopyranosyloxy)-1a,1b,2,5a,6,6a-hexahydro-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-6-yl ester, (2E)- |
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β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-O-[(2E)-1-oxo-3-phenyl-2-propen-1-yl]- |
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6′-O-trans-cinnamoylcatalpol |
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(1aS,1bS,2S,5aR,6S,6aS)-6-Hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-O-[(2E)-3-phenyl-2-propenoyl]-β-D-glucopyranoside |
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picrosides I |
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Picroside I |
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(1aS,1bS,2S,5aR,6S,6aS)-2-(β-D-Glucopyranosyloxy)-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-6-yl (2E)-3-phenylacrylate |
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