中文名 |
2-溴-1-(2,6-二氯苯基)乙酮 |
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英文名 |
2,3-dihydro-1,4-benzodioxin-6-yl(piperidin-1-yl)methanone |
中文别名 |
(2,3-二氢苯并[b][1,4]二噁英-6-基)(哌啶-1-基)甲酮 | 苯并二氧六环-6-(1-哌啶基)甲酰胺 | 1-(1,4-苯并二氧六环-6-基甲酰基)哌啶 |
英文别名 |
更多 |
描述 |
CX546是AMPAR受体选择性激动剂。 |
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相关类别 |
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溶解度 |
体外:
H 2 O:2 mg / mL(8.09 mM;需要超声波)
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储备液 |
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存储 |
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运输 |
室温;可能会有所不同 |
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SMILES |
O=C(N1CCCCC1)C2=CC=C(OCCO3)C3=C2 |
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参考文献 |
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相关活性 小分子 |
(+)-MK 801 马来酸盐(马来酸地佐环平)(mM/ml) | 6-氰基-7-硝基喹喔啉-2,3-二酮 | N-甲基-D-天冬氨酸水合物 | 酒石酸艾芬地尔 | (R)-(-)-2-氨基-5-膦酰戊酸 | 6,7-二硝基奎喔林-2,3(1H,4H)-二酮 | Ro 25-6981马来酸盐 | 马来酸氟吡汀 | Mibampator | Naspm | (8R)-7-乙酰基-5-(4-氨基苯基)-8,9-二氢-8-甲基-7H-1,3-二氧杂环戊烯并[4,5-H][2,3]苯并二氮杂卓 | 盐酸甲氯芬酯 | 24羟基胆固醇 | 阿尼西坦 |
密度 | 1.215g/cm3 |
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沸点 | 422.8?C at 760 mmHg |
分子式 | C14H17NO3 |
分子量 | 247.29000 |
闪点 | 209.5?C |
精确质量 | 247.12100 |
PSA | 38.77000 |
LogP | 2.02180 |
蒸汽压 | 2.34E-07mmHg at 25°C |
折射率 | 1.573 |
个人防护装备 |
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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危险品运输编码 | NONH for all modes of transport |
海关编码 | 2934999090 |
海关编码 | 2934999090 |
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中文概述 | 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
申报要素 | 品名, 成分含量, 用途 |
Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex. Eur. Psychiatry 29(7) , 419-23, (2014)
Ketamine exerts fast acting, robust, and lasting antidepressant effects in a sub-anesthetic dose, however, the underlying mechanisms are still not fully elucidated. Recent studies have suggested that …
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Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. J. Pharmacol. Exp. Ther. 303 , 1075-1085, (2002)
CX516 (BDP-12) and CX546, two first-generation benzamide-type AMPA receptor modulators, were compared with regard to their influence on AMPA receptor-mediated currents, autaptic responses in cultured …
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Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM. Proc. Natl. Acad. Sci. U. S. A. 95 , 2597-2602, (1998)
To study regulation in vivo of the promoter for the neural cell adhesion molecule, N-CAM, we have used homologous recombination to insert the bacterial lacZ gene between the transcription and translat…
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CX 546 |
Lopac-C-271 |
BDP 17 |
GR 87 |
CX546 |