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苯并二氧六环-6-(1-哌啶基)甲酰胺

苯并二氧六环-6-(1-哌啶基)甲酰胺

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?苯并二氧六环-6-(1-哌啶基)甲酰胺名称


















中文名

2-溴-1-(2,6-二氯苯基)乙酮
英文名

2,3-dihydro-1,4-benzodioxin-6-yl(piperidin-1-yl)methanone
中文别名


(2,3-二氢苯并[b][1,4]二噁英-6-基)(哌啶-1-基)甲酮




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苯并二氧六环-6-(1-哌啶基)甲酰胺




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1-(1,4-苯并二氧六环-6-基甲酰基)哌啶



英文别名
更多





?苯并二氧六环-6-(1-哌啶基)甲酰胺生物活性












































描述
CX546是AMPAR受体选择性激动剂。
相关类别





溶解度

体外:

H 2 O:2 mg / mL(8.09 mM;需要超声波)


储备液

1 mM 4.0438 mL 20.2192 mL 40.4384 mL
5 mM 0.8088 mL 4.0438 mL 8.0877 mL
10 mM 0.4044 mL 2.0219 mL 4.0438 mL


存储

粉末 -20℃下 3年
4℃下 2年
在溶剂中 -80℃下 6个月
-20℃下 1个月


运输

室温;可能会有所不同
SMILES

O=C(N1CCCCC1)C2=CC=C(OCCO3)C3=C2
参考文献

[1]. Lauterborn JC, et al. Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci. 2000 Jan 1;20(1):8-21.

[2]. Nagarajan N, et al. Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546. Neuropharmacology. 2001 Nov;41(6):650-63.

[3]. Arai AC, et al. Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. J Pharmacol Exp Ther. 2002 Dec;303(3):1075-85.

[4]. Lipina T, et al. The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice. Neuropsychopharmacology. 2007 Apr;32(4):745-56.


相关活性
小分子




(+)-MK 801 马来酸盐(马来酸地佐环平)(mM/ml)



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6-氰基-7-硝基喹喔啉-2,3-二酮



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N-甲基-D-天冬氨酸水合物



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酒石酸艾芬地尔



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(R)-(-)-2-氨基-5-膦酰戊酸



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6,7-二硝基奎喔林-2,3(1H,4H)-二酮



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Ro 25-6981马来酸盐



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马来酸氟吡汀



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Mibampator



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Naspm



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(8R)-7-乙酰基-5-(4-氨基苯基)-8,9-二氢-8-甲基-7H-1,3-二氧杂环戊烯并[4,5-H][2,3]苯并二氮杂卓



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盐酸甲氯芬酯



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24羟基胆固醇



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阿尼西坦






?苯并二氧六环-6-(1-哌啶基)甲酰胺物理化学性质



































密度 1.215g/cm3
沸点 422.8?C at 760 mmHg
分子式 C14H17NO3
分子量 247.29000
闪点 209.5?C
精确质量 247.12100
PSA 38.77000
LogP 2.02180
蒸汽压 2.34E-07mmHg at 25°C
折射率 1.573






?苯并二氧六环-6-(1-哌啶基)甲酰胺安全信息




















个人防护装备
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码 NONH for all modes of transport
海关编码 2934999090











?苯并二氧六环-6-(1-哌啶基)甲酰胺海关















海关编码 2934999090
中文概述 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%








?苯并二氧六环-6-(1-哌啶基)甲酰胺文献5

更多文献














Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex.

Eur. Psychiatry 29(7) , 419-23, (2014)

Ketamine exerts fast acting, robust, and lasting antidepressant effects in a sub-anesthetic dose, however, the underlying mechanisms are still not fully elucidated. Recent studies have suggested that …





Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action.

J. Pharmacol. Exp. Ther. 303 , 1075-1085, (2002)

CX516 (BDP-12) and CX546, two first-generation benzamide-type AMPA receptor modulators, were compared with regard to their influence on AMPA receptor-mediated currents, autaptic responses in cultured …





Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM.

Proc. Natl. Acad. Sci. U. S. A. 95 , 2597-2602, (1998)

To study regulation in vivo of the promoter for the neural cell adhesion molecule, N-CAM, we have used homologous recombination to insert the bacterial lacZ gene between the transcription and translat…









?苯并二氧六环-6-(1-哌啶基)甲酰胺英文别名
























CX 546


Lopac-C-271


BDP 17


GR 87


CX546








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